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• W2064546838 abstract "We compared the G-protein requirements for coupling of human and chicken m2 and m4 muscarinic acetylcholine receptors (mAChRs) to inhibition of adenylyl cyclase, using a luciferase reporter gene under the transcriptional control of a cAMP response element as a sensitive monitor of intracellular cAMP levels. Previously, we used this system to demonstrate that the chick m4 receptor preferentially coupled to Giα-2 and Goα over Giα-1 and Giα-3. We found that both the chick and human m2 mAChRs can couple to Giα-1, Giα-2, Giα-3, and Goα, while the human m4 mAChR preferentially couples to Giα-2 and Goα. Both the Go1 and Go2 forms of the Goα subunit were effective in reconstituting coupling of the m2 and m4 mAChRs to inhibit adenylyl cyclase activity. The m2 and m4 mAChRs thus couple to inhibition of adenylyl cyclase by overlapping but different sets of G-protein α subunits. We compared the G-protein requirements for coupling of human and chicken m2 and m4 muscarinic acetylcholine receptors (mAChRs) to inhibition of adenylyl cyclase, using a luciferase reporter gene under the transcriptional control of a cAMP response element as a sensitive monitor of intracellular cAMP levels. Previously, we used this system to demonstrate that the chick m4 receptor preferentially coupled to Giα-2 and Goα over Giα-1 and Giα-3. We found that both the chick and human m2 mAChRs can couple to Giα-1, Giα-2, Giα-3, and Goα, while the human m4 mAChR preferentially couples to Giα-2 and Goα. Both the Go1 and Go2 forms of the Goα subunit were effective in reconstituting coupling of the m2 and m4 mAChRs to inhibit adenylyl cyclase activity. The m2 and m4 mAChRs thus couple to inhibition of adenylyl cyclase by overlapping but different sets of G-protein α subunits." @default.
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• W2064546838 date "1995-07-01" @default.
• W2064546838 modified "2023-10-12" @default.
• W2064546838 title "Differential Coupling of m2 and m4 Muscarinic Receptors to Inhibition of Adenylyl Cyclase by Giα and Goα Subunits" @default.
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• W2064546838 doi "https://doi.org/10.1074/jbc.270.27.16070" @default.
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