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- W2064549642 abstract "This studyanalysed the biological relevance of E-cadherin, α-catenin, β-catenin and γ-catenin immunoexpression pattern (reduced vs. preserved phenotype) in epithelial ovarian tumours. Immunohistochemistry was used to evaluate the expression of these proteins in 154 epithelial ovarian tumours, consisting of 17 benign, 33 borderline and 104 malignant tumours. In borderline tumours, the immunoexpression pattern of E-cadherin (p <i>= </i>0.014) and α-catenin (p <i>= </i>0.030) associated with histological type. In malignant tumours, the immunoexpression pattern of E-cadherin was related with histological type (p<i> = </i>0.001). The immunoexpression pattern of β-catenin associated with histological type and tumour differentiation (p<i> = </i>0.005, p<i> = </i>0.025, respectively). The preserved phenotype of E-cadherin was most frequently observed in mucinous tumours, whereas reduced E-cadherin was most frequently observed in serous tumours. The preserved phenotype of β-catenin associated with endometrioid carcinomas, while reduced β-catenin associated with poorly differentiated serous and clear cell carcinomas. Although the reduced phenotype was the most frequent immunoexpression observed for all proteins of the E-cadherin-catenin complex in epithelial ovarian tumours, only β-catenin showed a significant difference between benign, borderline and malignant tumours (p <i>= </i>0.045), since borderline and malignant tumours most frequently showed the reduced phenotype. The immunohistochemical profile of β-catenin was shown to be of biological relevance: reduced β-catenin was correlated with loss of tumour differentiation and serous carcinomas that are known to depict aggressive biological behaviour in epithelial ovarian tumours." @default.
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- W2064549642 date "2005-01-01" @default.
- W2064549642 modified "2023-10-17" @default.
- W2064549642 title "Biological Relevance of E-Cadherin-Catenin Complex Proteins in Primary Epithelial Ovarian Tumours" @default.
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- W2064549642 doi "https://doi.org/10.1159/000084614" @default.
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