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- W2064550003 abstract "The mechanical effects of KCl, oxytocin and endothelin-1 on pregnant rat myometrium were examined using intact strips and β-escin-treated skinned strips. Myometrial tissues from delivering rats were more sensitive to 10.7 mM K+ compared to mid and late gestation. Maximum contractions induced by K+ were obtained at concentrations of 118 mM at mid and late gestation and during delivery. The maximum amplitude of contractions induced by oxytocin and endothelin-1 compared to the 118 mM K+-induced contraction increased during the progress of gestation. Maximum contractions induced by oxytocin and endothelin-1 were greater than those induced by 118 mM K+ at delivery, and maximum contractions by oxytocin were larger than those by endothelin-1 during delivery. In 10 μM nifedipine and Ca2+-free (containing 2 mM EGTA) solutions, 118 mM K+ contractions were completely abolished; however, both oxytocin and endothelin-1 produced contractions. In Ca2+-free solutions, contractions by oxytocin were larger than those by endothelin-1. In skinned myometrial strips, guanosine 5′-O-thiotriphosphate (GTP, 1 μM-1 mM), guanosine 5′-O-(γ-thiotriphosphate) (GTPγS, 0.1–10 μM) and oxytocin (1 nM-0.1 μM) with 10 μM GTP, but not endothelin-1 with 10 μM GTP increased Ca2+ sensitivity of contractile force. These results suggests that (1) the membrane permeability for Ca2+ and the number of receptors of oxytocin and endothelin-1 increase during the progress of gestation, (2) both oxytocin and endothelin-1 produce contractions by activation of voltage-dependent Ca2+ channels and Ca2+ release from internal storage sites, (3) oxytocin, but not endothelin-1, coupled to receptors increases Ca2+ sensitivity to contractile proteins." @default.
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- W2064550003 title "Gestational changes in oxytocin- and endothelin-1-induced contractility of pregnant rat myometrium" @default.
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- W2064550003 doi "https://doi.org/10.1016/0014-2999(95)00089-4" @default.
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