FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064553485> ?p ?o ?g. }

• W2064553485 endingPage "9578" @default.
• W2064553485 startingPage "9568" @default.
• W2064553485 abstract "The transcriptional coactivator Yes-associated protein (YAP) has been implicated in tumorigenesis by regulating cell proliferation and apoptosis. YAP interacts with the transcription factor TEAD and is essential in mediating TEAD-dependent gene expression. Here we show that YAP is hyperphosphorylated and activated in response to genotoxic stress such as UV irradiation and cisplatin treatment. Using high resolution mobility shift assay for phosphorylated proteins, we identified multiple sites of phosphorylation induced by UV irradiation. Pretreatment with p38 and JNK inhibitors completely suppressed the mobility retardation of phosphorylated YAP in UV-irradiated cells. Co-immunoprecipitation experiments showed that the physical interaction of YAP with TEAD was markedly enhanced by UV irradiation or CDDP treatment but suppressed by pretreatment with p38 and JNK inhibitors. Similarly, pretreatment with p38 and JNK inhibitors suppressed the expression of YAP/TEAD target genes, which were elevated on exposure to genotoxic stress. Using phosphomimetic and phosphorylation-deficient YAP mutants, we showed that the coactivator activity of YAP correlated with its state of phosphorylation and sensitivity to cisplatin-induced apoptosis. Our results demonstrate that multisite phosphorylation of YAP induces YAP/TEAD-dependent gene expression and provides a mechanism by which YAP regulates apoptosis differently depending on cellular context." @default.
• W2064553485 created "2016-06-24" @default.
• W2064553485 creator A5036360676 @default.
• W2064553485 creator A5042850783 @default.
• W2064553485 date "2012-03-01" @default.
• W2064553485 modified "2023-10-13" @default.
• W2064553485 title "Identification of Mechanism That Couples Multisite Phosphorylation of Yes-associated Protein (YAP) with Transcriptional Coactivation and Regulation of Apoptosis" @default.
• W2064553485 cites W1531523780 @default.
• W2064553485 cites W1584759442 @default.
• W2064553485 cites W1963927300 @default.
• W2064553485 cites W1974037176 @default.
• W2064553485 cites W1974762803 @default.
• W2064553485 cites W1978746441 @default.
• W2064553485 cites W1987007903 @default.
• W2064553485 cites W1996420367 @default.
• W2064553485 cites W1998310906 @default.
• W2064553485 cites W2003111150 @default.
• W2064553485 cites W2007916618 @default.
• W2064553485 cites W2011818472 @default.
• W2064553485 cites W2012758205 @default.
• W2064553485 cites W2022423243 @default.
• W2064553485 cites W2034469841 @default.
• W2064553485 cites W2034807490 @default.
• W2064553485 cites W2038441458 @default.
• W2064553485 cites W2046985565 @default.
• W2064553485 cites W2050774616 @default.
• W2064553485 cites W2071765960 @default.
• W2064553485 cites W2075452487 @default.
• W2064553485 cites W2079943669 @default.
• W2064553485 cites W2081647550 @default.
• W2064553485 cites W2095891777 @default.
• W2064553485 cites W2099709490 @default.
• W2064553485 cites W2101538557 @default.
• W2064553485 cites W2104726963 @default.
• W2064553485 cites W2118671972 @default.
• W2064553485 cites W2124059822 @default.
• W2064553485 cites W2128021675 @default.
• W2064553485 cites W2129777487 @default.
• W2064553485 cites W2135726634 @default.
• W2064553485 cites W2141595533 @default.
• W2064553485 cites W2142021109 @default.
• W2064553485 cites W2146337514 @default.
• W2064553485 cites W2151260549 @default.
• W2064553485 cites W2159196011 @default.
• W2064553485 cites W2159310898 @default.
• W2064553485 cites W2159376228 @default.
• W2064553485 cites W2167978765 @default.
• W2064553485 doi "https://doi.org/10.1074/jbc.m111.296954" @default.
• W2064553485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4813504" @default.
• W2064553485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26921413" @default.
• W2064553485 hasPublicationYear "2012" @default.
• W2064553485 type Work @default.
• W2064553485 sameAs 2064553485 @default.
• W2064553485 citedByCount "34" @default.
• W2064553485 countsByYear W20645534852013 @default.
• W2064553485 countsByYear W20645534852014 @default.
• W2064553485 countsByYear W20645534852015 @default.
• W2064553485 countsByYear W20645534852016 @default.
• W2064553485 countsByYear W20645534852017 @default.
• W2064553485 countsByYear W20645534852018 @default.
• W2064553485 countsByYear W20645534852019 @default.
• W2064553485 countsByYear W20645534852020 @default.
• W2064553485 countsByYear W20645534852021 @default.
• W2064553485 countsByYear W20645534852022 @default.
• W2064553485 countsByYear W20645534852023 @default.
• W2064553485 crossrefType "journal-article" @default.
• W2064553485 hasAuthorship W2064553485A5036360676 @default.
• W2064553485 hasAuthorship W2064553485A5042850783 @default.
• W2064553485 hasBestOaLocation W20645534851 @default.
• W2064553485 hasConcept C104317684 @default.
• W2064553485 hasConcept C11960822 @default.
• W2064553485 hasConcept C153911025 @default.
• W2064553485 hasConcept C185592680 @default.
• W2064553485 hasConcept C190283241 @default.
• W2064553485 hasConcept C502942594 @default.
• W2064553485 hasConcept C51551487 @default.
• W2064553485 hasConcept C54355233 @default.
• W2064553485 hasConcept C77445288 @default.
• W2064553485 hasConcept C86339819 @default.
• W2064553485 hasConcept C86803240 @default.
• W2064553485 hasConcept C95444343 @default.
• W2064553485 hasConcept C97029542 @default.
• W2064553485 hasConceptScore W2064553485C104317684 @default.
• W2064553485 hasConceptScore W2064553485C11960822 @default.
• W2064553485 hasConceptScore W2064553485C153911025 @default.
• W2064553485 hasConceptScore W2064553485C185592680 @default.
• W2064553485 hasConceptScore W2064553485C190283241 @default.
• W2064553485 hasConceptScore W2064553485C502942594 @default.
• W2064553485 hasConceptScore W2064553485C51551487 @default.
• W2064553485 hasConceptScore W2064553485C54355233 @default.
• W2064553485 hasConceptScore W2064553485C77445288 @default.
• W2064553485 hasConceptScore W2064553485C86339819 @default.
• W2064553485 hasConceptScore W2064553485C86803240 @default.
• W2064553485 hasConceptScore W2064553485C95444343 @default.
• W2064553485 hasConceptScore W2064553485C97029542 @default.
• W2064553485 hasIssue "12" @default.
• W2064553485 hasLocation W20645534851 @default.
• W2064553485 hasLocation W20645534852 @default.

• next