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- W2064553559 abstract "Cerebral amyloid angiopathy (CAA) is caused by the deposition of amyloid (Aß) in the cerebral vasculature. The transgenic mice that express the Swedish, Dutch and Iowa APP mutations (Tg-SwDI) present with very early and rapid accumulation of Aß, which is closely associated with the microvasculature (Davis et al. 2004), modelling early-onset CAA. Due to the vascular accumulation of Aß,cerebral blood flow is decreased (Chow et al. 2007). Chronic cerebral hypoperfusion has been shown to lead to white matter damage and deficits in spatial working memory (Coltmanet al. 2010). This study was aimed at determining the temporal effect of Aß accumulation on white matter and cerebrovascular integrity in parallel with cognition. Three-, six- and nine-month old male, homozygous TgSwDI mice with their respective age-matched controls were assessed for temporal changes of various pathological features of CAA and AD including Aß deposition in and around the microvasculature. Six- and nine-month old animals were first behaviourally characterized using hippocampal-dependent memory tasks including the Y-maze. Subsequently brains were processed for ex vivo imaging to assess white matter integrity prior to immunohistochemical and biochemical analysis to assess cerebrovascular and white matter integrity. Three-month old animals show early and rapid accumulation of Aß, specifically in the subiculum of the hippocampus as has been previously reported (Xu et al.2007). Data will be presented showing age-dependent effects on spatial memory, white matter integrity, and cerebral microvasculature in the context of increasing Aß deposition in the vasculature of Tg-SwDI transgenic mice. The results of this study have implications on the effects of vascular Aß deposition on cognition and how it relates to cerebrovascualar as well as white matter integrity." @default.
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- W2064553559 date "2011-07-01" @default.
- W2064553559 modified "2023-09-27" @default.
- W2064553559 title "P4-039: Temporal influence of CAA on cerebrovascular and white matter integrity in parallel with cognition in Tg-SwDI mice" @default.
- W2064553559 doi "https://doi.org/10.1016/j.jalz.2011.05.2059" @default.
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