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• W2064557409 abstract "Abstract BACKGROUND: Human papillomavirus (HPV) 16/18 infection is associated with nonsmoking lung cancer. In this study, the authors investigated a putative correlation between interleukin (IL)‐17 expression and HPV infection in clinical nonsmall cell lung cancer (NSCLC) tissues and examined the effects of HPV infection on a human NSCLC cell line. METHODS: IL‐17 expression was investigated in 79 NSCLC tumor tissues by immunohistochemistry. Growth rate, IL‐17 mRNA, and secreting protein levels were also examined in HPV 16/18 E6‐transfected H1299 human NSCLC cells. RESULTS: Immunohistochemical data showed that 48.1% of lung tumors had IL‐17 staining, which was significantly associated with patients' sex ( P = .03), HPV infection ( P = .002), and tumor stage ( P = .03). Significant correlations of IL‐17 with IL‐6 ( P < .001) and IL‐17 with Mcl‐1 ( P < .001) expression were also observed. Cell growth rate was increased, and IL‐17/Mcl‐1 expression levels were elevated in HPV 16 E6‐transfected H1299 cells. The transfected E6 oncoproteins can significantly up‐regulate expression levels of IL‐17 and antiapoptotic protein Mcl‐1. CONCLUSIONS: The study suggests that HPV infection‐induced IL‐17 levels can stimulate Mcl‐1 expression through the PI3K pathway and promote lung tumor cell progression through a p53‐ and IL‐6‐independent pathway. Cancer 2010. © 2010 American Cancer Society." @default.
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• W2064557409 date "2010-06-24" @default.
• W2064557409 modified "2023-10-12" @default.
• W2064557409 title "Up-regulation of interleukin-17 expression by human papillomavirus type 16 E6 in nonsmall cell lung cancer" @default.
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• W2064557409 doi "https://doi.org/10.1002/cncr.25224" @default.
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