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- W2064577891 abstract "Many strains of rats develop adrenal medullary hyperplasia and/or neoplasia after chronic administration of a wide variety of pharmacologic agents. The same changes may occur spontaneously in the course of aging. Current evidence suggests that chromaffin cell proliferation in adult rats is regulated by a combination of hormonal and neurogenic signals. Drugs associated with adrenal medullary tumors might act directly or indirectly on the hypothalamic-endocrine axis or the autonomic nervous system to stimulate chromaffin cell proliferation through mechanisms which normally adjust cell number to meet physiological needs. The increased cell turnover rate might be a prelude to other events leading to neoplastic transformation." @default.
- W2064577891 created "2016-06-24" @default.
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- W2064577891 date "1989-01-01" @default.
- W2064577891 modified "2023-10-16" @default.
- W2064577891 title "Pharmacological stimulation of chromaffin cell proliferation in the adult adrenal medulla." @default.
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- W2064577891 doi "https://doi.org/10.1679/aohc.52.suppl_209" @default.
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