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• W2064580246 startingPage "15787" @default.
• W2064580246 abstract "Mutations in either of two human presenilin genes ( PS1 and PS2 ) cause Alzheimer’s disease. Here we describe genetic and physical interactions between Caenorhabditis elegans SEL-10, a member of the Cdc4p family of proteins, and SEL-12, a C. elegans presenilin. We show that loss of sel-10 activity can suppress the egg-laying defective phenotype associated with reducing sel-12 activity, and that SEL-10 can physically complex with SEL-12. Proteins of the Cdc4p family have been shown to target proteins for ubiquitin-mediated turnover. The functional and physical interaction between sel-10 and sel-12 therefore offers an approach to understanding how presenilin levels are normally regulated." @default.
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• W2064580246 date "1998-12-22" @default.
• W2064580246 modified "2023-09-23" @default.
• W2064580246 title "Evidence for functional and physical association between <i>Caenorhabditis elegans</i> SEL-10, a Cdc4p-related protein, and SEL-12 presenilin" @default.
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• W2064580246 doi "https://doi.org/10.1073/pnas.95.26.15787" @default.
• W2064580246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/28122" @default.
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