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- W2064580314 abstract "To identify genes that are expressed in MS pathogenesis, we have analyzed a normalized cDNA library made from mRNA obtained from CNS lesions of a patient with primary progressive MS. Complementary DNA clones obtained from this library were subjected to automated DNA sequencing to generate expressed sequence tags. Analysis of this MS cDNA library revealed the presence of 54 cDNAs that were associated with immune activation and indicated the presence of an ongoing inflammatory response with evidence of both cell-mediated and humoral immune responses. The surprising finding was that 16 of the cDNAs encoded autoantigens associated with seven other autoimmune disorders, while only three of these 16 autoantigen cDNAs were present in a similarly constructed adult brain library. Such aberrant autoantigen expression could provide a source of secondary autoimmune stimulation that could contribute to the ongoing inflammatory response in MS. In addition, two cDNAs were found that mapped to a known MS susceptibility locus (5p14-p12): one encoded an excitatory amino acid transporter and the other a human homologue of the Drosophila disabled gene. This approach to the molecular biology of MS pathogenesis may help to illuminate previously unappreciated aspects of this disease." @default.
- W2064580314 created "2016-06-24" @default.
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- W2064580314 date "1997-07-01" @default.
- W2064580314 modified "2023-10-12" @default.
- W2064580314 title "Analysis of a sequenced cDNA library from multiple sclerosis lesions" @default.
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- W2064580314 doi "https://doi.org/10.1016/s0165-5728(97)00045-3" @default.
- W2064580314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9209265" @default.
- W2064580314 hasPublicationYear "1997" @default.
- W2064580314 type Work @default.