Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064589283> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2064589283 abstract "In our study, nitrofurantoin (NF) and nitrofurazone (NZ) inhibited respiration of isolated mouse (C57B/6J, adult, male) liver mitochondria. Other aromatic nitro compounds, nitroimidazole, metronidazole, and p-nitrobenzoic acid, did not have any significant effect. The primary site of activity for NF was complex I NADH-ubiquinone oxidoreductase mediated respiration, since only complex I substrates, glutamate, beta-hydroxybutyrate, and alpha-ketoglutarate-mediated respiration were decreased. Respiration supported by succinate, a complex II substrate, was not affected by any of the compounds. NF at a concentration of 50 microM decreased state 3 and dinitrophenol-uncoupled respiration to 28 +/- 1 and 25 +/- 5% of control, respectively, of mitochondria oxidizing glutamate. Studies with mitoplasts oxidizing glutamate showed that NF inhibited both state 3 and 4 respiration. The inhibition of state 3 was prevented by the simultaneous addition of superoxide dismutase (240 micrograms/ml) and catalase (200 micrograms/ml). These results suggest that the mitochondrion, in particular complex I of the electron transport system, is a target for NF toxicity. The effect on respiration may be mediated by NF redox cycling and the generation of reactive oxygen intermediates resulting in the interference of electron flow." @default.
- W2064589283 created "2016-06-24" @default.
- W2064589283 creator A5005849249 @default.
- W2064589283 creator A5019863646 @default.
- W2064589283 creator A5080611905 @default.
- W2064589283 date "1986-07-01" @default.
- W2064589283 modified "2023-09-27" @default.
- W2064589283 title "Nitrofurantoin inhibition of mouse liver mitochondrial respiration involving NAD-linked substrates" @default.
- W2064589283 cites W1492322138 @default.
- W2064589283 cites W1506043065 @default.
- W2064589283 cites W1510552705 @default.
- W2064589283 cites W1544184909 @default.
- W2064589283 cites W1569494491 @default.
- W2064589283 cites W1579149940 @default.
- W2064589283 cites W1579508640 @default.
- W2064589283 cites W1599899083 @default.
- W2064589283 cites W1880095270 @default.
- W2064589283 cites W1964041346 @default.
- W2064589283 cites W1971181420 @default.
- W2064589283 cites W1984942439 @default.
- W2064589283 cites W1987238736 @default.
- W2064589283 cites W1991354483 @default.
- W2064589283 cites W2007348580 @default.
- W2064589283 cites W2019588258 @default.
- W2064589283 cites W2041610853 @default.
- W2064589283 cites W2050357506 @default.
- W2064589283 cites W2050823569 @default.
- W2064589283 cites W2078804081 @default.
- W2064589283 cites W2080501796 @default.
- W2064589283 cites W2086783188 @default.
- W2064589283 cites W2138128197 @default.
- W2064589283 cites W2271272206 @default.
- W2064589283 cites W2441574277 @default.
- W2064589283 doi "https://doi.org/10.1016/0041-008x(86)90254-1" @default.
- W2064589283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3726872" @default.
- W2064589283 hasPublicationYear "1986" @default.
- W2064589283 type Work @default.
- W2064589283 sameAs 2064589283 @default.
- W2064589283 citedByCount "18" @default.
- W2064589283 countsByYear W20645892832016 @default.
- W2064589283 countsByYear W20645892832018 @default.
- W2064589283 countsByYear W20645892832019 @default.
- W2064589283 countsByYear W20645892832021 @default.
- W2064589283 crossrefType "journal-article" @default.
- W2064589283 hasAuthorship W2064589283A5005849249 @default.
- W2064589283 hasAuthorship W2064589283A5019863646 @default.
- W2064589283 hasAuthorship W2064589283A5080611905 @default.
- W2064589283 hasConcept C181199279 @default.
- W2064589283 hasConcept C182215343 @default.
- W2064589283 hasConcept C185592680 @default.
- W2064589283 hasConcept C24840226 @default.
- W2064589283 hasConcept C2778979269 @default.
- W2064589283 hasConcept C28859421 @default.
- W2064589283 hasConcept C55493867 @default.
- W2064589283 hasConcept C59822182 @default.
- W2064589283 hasConcept C66517615 @default.
- W2064589283 hasConcept C75520062 @default.
- W2064589283 hasConcept C86803240 @default.
- W2064589283 hasConceptScore W2064589283C181199279 @default.
- W2064589283 hasConceptScore W2064589283C182215343 @default.
- W2064589283 hasConceptScore W2064589283C185592680 @default.
- W2064589283 hasConceptScore W2064589283C24840226 @default.
- W2064589283 hasConceptScore W2064589283C2778979269 @default.
- W2064589283 hasConceptScore W2064589283C28859421 @default.
- W2064589283 hasConceptScore W2064589283C55493867 @default.
- W2064589283 hasConceptScore W2064589283C59822182 @default.
- W2064589283 hasConceptScore W2064589283C66517615 @default.
- W2064589283 hasConceptScore W2064589283C75520062 @default.
- W2064589283 hasConceptScore W2064589283C86803240 @default.
- W2064589283 hasLocation W20645892831 @default.
- W2064589283 hasLocation W20645892832 @default.
- W2064589283 hasOpenAccess W2064589283 @default.
- W2064589283 hasPrimaryLocation W20645892831 @default.
- W2064589283 hasRelatedWork W1967100195 @default.
- W2064589283 hasRelatedWork W1968916084 @default.
- W2064589283 hasRelatedWork W1979706678 @default.
- W2064589283 hasRelatedWork W1992282125 @default.
- W2064589283 hasRelatedWork W2014167033 @default.
- W2064589283 hasRelatedWork W2057981436 @default.
- W2064589283 hasRelatedWork W2064589283 @default.
- W2064589283 hasRelatedWork W2371896724 @default.
- W2064589283 hasRelatedWork W2414991052 @default.
- W2064589283 hasRelatedWork W3130380361 @default.
- W2064589283 isParatext "false" @default.
- W2064589283 isRetracted "false" @default.
- W2064589283 magId "2064589283" @default.
- W2064589283 workType "article" @default.