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• W2064593722 abstract "Editorials1 December 1992The Low Efficiency of Maternal-Neonatal Transmission of Hepatitis C Virus: How Certain Are We?Raymond S. Koff, MDRaymond S. Koff, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-11-967 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHepatitis C virus (HCV) is a hot topic. Because the literature is constantly expanding, keeping current with new research is no simple task for either the clinician or investigator. The big bang of HCV research is readily traced to the brilliant efforts and perseverance of Houghton and colleagues who, working collaboratively with Bradley, cloned the HCV genome (1). This remarkable achievement permitted a proliferation of specific assays to study HCV infection. The humoral immune response to HCV was assessed initially by radioimmunoassay, but the development of first-generation enzyme-linked immunosorbent assays (ELISAs) and recombinant immunoblot assays (RIBAs) and then second-generation assays...References1. ChooKuoWeinerOverbyBradleyHoughton QGALDM. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989;244:359-62. CrossrefMedlineGoogle Scholar2. ChaudharyMacLean RC. Evaluation of first- and second-generation RIBA kits for detection of antibody to hepatitis C virus. J Clin Microbiol. 1991;29:2329-30. CrossrefMedlineGoogle Scholar3. McHutchisonPersonGovindarajanValinluckGoreLee JJSBTS. Improved detection of hepatitis C virus antibodies in high-risk populations. Hepatology. 1992;15:19-25. CrossrefMedlineGoogle Scholar4. VallariJettAlterMimmsHolzmanShih DBHLRJ. Serological markers of posttransfusion hepatitis C viral infection. J Clin Microbiol. 1992;30:552-6. CrossrefMedlineGoogle Scholar5. WangWangLinSheuLeeChen JTJJCD. Improved serodiagnosis of posttransfusion hepatitis C virus infection by a second-generation immunoassay based on multiple recombinant antigens. Vox Sang. 1992;62:21-4. CrossrefMedlineGoogle Scholar6. KotwalRustgiBaroudy GVB. Detection of hepatitis C virus-specific antigens in semen from non-A, non-B hepatitis patients. Dig Dis Sci. 1992;37:641-4. CrossrefMedlineGoogle Scholar7. TakahashiOkamotoKishimotoMunekataTachibanaAkahane KHSEKY. Demonstration of a hepatitis C virus-specific antigen predicted from the putative core gene in the circulation of infected hosts. J Gen Virol. 1992;73:667-72. CrossrefMedlineGoogle Scholar8. KrawczynskiBeachBradleyKuodi BisceglieHoughton KMDGAM. Hepatitis C virus antigen in hepatocytes: immunomorphologic detection and identification. Gastroenterology. 1992; 103:622-9. CrossrefMedlineGoogle Scholar9. YamadaKojiNozawaKiyosawaNakane STMKP. Detection of hepatitis C virus (HCV) RNA in paraffin-embedded tissue sections of human liver of non-A, non-B hepatitis patients by in situ hybridization. J Clin Lab Anal. 1992;6:40-6. CrossrefMedlineGoogle Scholar10. DonahueMunozNessBrownYawnMcAllister JAPDDH. The declining risk of post-transfusion hepatitis C virus infection. N Engl J Med. 1992;327:369-73. CrossrefMedlineGoogle Scholar11. SugitaniInchauspeShindoPrince MHMA. Sensitivity of serological assays to identify blood donors with hepatitis C viraemia. Lancet. 1992;339:1018-9. CrossrefMedlineGoogle Scholar12. NowakGregersenKlockmannCumminsHilfenhaus TJULJ. Virus safety of human immunoglobulins: efficient inactivation of hepatitis C and other human pathogenic viruses by the manufacturing procedure. J Med Virol. 1992;36:209-16. CrossrefMedlineGoogle Scholar13. ReinusLeikinAlterCheungShindoJett JEHLMB. Failure to detect vertical transmission of hepatitis C virus. Ann Intern Med. 1992;117:881-6. LinkGoogle Scholar14. 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Follow-up of hepatitis C virus infection in chimpanzees: determination of viraemia and specific humoral immune response. J Gen Virol. 1992;73:1015-9. CrossrefMedlineGoogle Scholar20. WangWangSheuLinLinChen JTJSJD. Effects of anticoagulants and storage of blood samples on efficacy of the polymerase chain reaction assay for hepatitis C virus. J Clin Microbiol. 1992;30:750-3. CrossrefMedlineGoogle Scholar21. ChaBeallIrvineKolbergChienKuo TEBJDG. At least five related, but distinct, hepatitis C viral genotypes exist. Proc Natl Acad Sci USA. 1992;89:7144-8. CrossrefMedlineGoogle Scholar22. InchauspeAbeZebedeeNasoffPrince GKSMA. Use of conserved sequences from hepatitis C virus for the detection of viral RNA in infected sera by polymerase chain reaction. Hepatology. 1991;14:595-600. CrossrefMedlineGoogle Scholar23. BukhPurcellMiller JRR. Sequence analysis of the 5′ non-coding region of hepatitis C virus. Proc Natl Acad Sci USA. 1992; 89:4942-6. CrossrefMedlineGoogle Scholar24. LeeChengWangLumeng CCJL. Identification of hepatitis C viruses with a nonconserved sequence of the 5′ untranslated region. J Clin Microbiol. 1992;30:1602-4. CrossrefMedlineGoogle Scholar25. HsuWrightLubaMartinFeinstoneGarcie HTDMSG. Failure to detect hepatitis C virus genome in human secretions with the polymerase chain reaction. Hepatology. 1991;14:763-7. CrossrefMedlineGoogle Scholar26. WangWantSheuLinChen JTJJD. Hepatitis C virus RNA in saliva of patients with posttransfusion hepatitis and low efficiency of transmission among spouses. J Med Virol. 1992; 36:28-31. CrossrefMedlineGoogle Scholar27. ChaKolbergIrvineStempienBeallYano TJBMEM. Use of a signature nucleotide sequence of hepatitis C virus for detection of viral RNA in human serum and plasma. J Clin Microbiol. 1991;29:2528-34. CrossrefMedlineGoogle Scholar28. HuYuVierling KCJ. Direct detection of circulating hepatitis C virus RNA using probes from the 5′-untranslated region. J Clin Invest. 1992;89:2040-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Massachusetts Medical Center MetroWest Medical Center Framingham, MA 01701 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLiver DiseasesHepatitis C: an epidemiological reviewContaining Hepatitis CBases décisionnelles d'un essai de prophylaxie de la transmission périnatale de l'hépatite C par immunoglobulines spécifiquesVertical transmission of hepatitis C Virus: An epidemiological study on 2,980 pregnant women in ItalyVertical Transmission of Hepatitis C Virus InfectionVirus infections in pregnancyEpidemiology and prevention of hepatitis type C in ItalyThe mammography and prostate-specific antigen controversiesTransmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulinMulti-organ donor transmission of hepatitis C virus to five solid organ transplant recipients and lack of transmission to corneal transplant recipientsViral hepatitisHeterosexual transmission of hepatitis C virus and the possible role of coexistent human immunodeficiency virus infection in the index case: A multicentre study of 423 pairingsPrevalence of antibodies against hepatitis B and C virus among pregnant women and female blood donors in SwedenHepatitis C virus infection from blood and blood productsTransmission of Hepatitis C Virus from Mothers to InfantsManagement of chronic hepatitis in special populations 1 December 1992Volume 117, Issue 11Page: 967-969KeywordsEnzyme linked immunosorbent assayHepatitis C virusHospital medicineHumoral immune responseRadioimmunoassays Issue Published: 1 December 1992 PDF downloadLoading ..." @default.
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