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- W2064594769 abstract "A general principle that has emerged from the study of intercellular signals is that these agents often promote both rapidly onsetting and delayed responses. For example, insulin enhances the uptake of glucose within minutes of its application to target cells. In contrast, other responses to insulin, such as stimulation of DNA synthesis, are apparent only after latencies of tens of hours. The object of this article is to review evidence that nerve growth factor (NGF), a protein with a variety of actions on vertebrate dorsal root sensory and sympathetic neurons1–3, also triggers both rapid and delayed responses. In addition, we raise the issue that the highly asymmetric form of neurons as well as their trophic interactions have brought this duality of action to an especially, and perhaps uniquely, important role in the nervous system." @default.
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- W2064594769 date "1984-03-01" @default.
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- W2064594769 title "The importance of both early and delayed responses in the biological actions of nerve growth factor" @default.
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- W2064594769 doi "https://doi.org/10.1016/s0166-2236(84)80164-2" @default.
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