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- W2064600878 abstract "Fifty years ago, FitzHugh introduced a phase portrait that became famous for a twofold reason: it captured in a physiological way the qualitative behavior of Hodgkin-Huxley model and it revealed the power of simple dynamical models to unfold complex firing patterns. To date, in spite of the enormous progresses in qualitative and quantitative neural modeling, this phase portrait has remained a core picture of neuronal excitability. Yet, a major difference between the neurophysiology of 1961 and of 2011 is the recognition of the prominent role of calcium channels in firing mechanisms. We show that including this extra current in Hodgkin-Huxley dynamics leads to a revision of FitzHugh-Nagumo phase portrait that affects in a fundamental way the reduced modeling of neural excitability. The revisited model considerably enlarges the modeling power of the original one. In particular, it captures essential electrophysiological signatures that otherwise require non-physiological alteration or considerable complexification of the classical model. As a basic illustration, the new model is shown to highlight a core dynamical mechanism by which calcium channels control the two distinct firing modes of thalamocortical neurons." @default.
- W2064600878 created "2016-06-24" @default.
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- W2064600878 date "2012-08-08" @default.
- W2064600878 modified "2023-09-23" @default.
- W2064600878 title "A Novel Phase Portrait for Neuronal Excitability" @default.
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- W2064600878 doi "https://doi.org/10.1371/journal.pone.0041806" @default.
- W2064600878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3414513" @default.
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