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- W2064607534 abstract "Irrespective of aetiology, persistent pulmonary hypertension of the newborn is associated with failure of the pulmonary circulation to adapt normally to extrauterine life. This chapter discusses the pathological features of persistent pulmonary hypertension, idiopathic and secondary, the mechanisms determining pulmonary vascular resistance in the perinatal period and the reciprocal relationship between postnatal structural remodelling of the pulmonary arteries and pulmonary vascular resistance. Despite the diversity of aetiology in babies with PPHN, it seems likely that while the trigger may be different they share a common defect in the cellular mechanisms determining the postnatal fall in pulmonary vascular resistance. Irrespective of aetiology, persistent pulmonary hypertension of the newborn is associated with failure of the pulmonary circulation to adapt normally to extrauterine life. This chapter discusses the pathological features of persistent pulmonary hypertension, idiopathic and secondary, the mechanisms determining pulmonary vascular resistance in the perinatal period and the reciprocal relationship between postnatal structural remodelling of the pulmonary arteries and pulmonary vascular resistance. Despite the diversity of aetiology in babies with PPHN, it seems likely that while the trigger may be different they share a common defect in the cellular mechanisms determining the postnatal fall in pulmonary vascular resistance." @default.
- W2064607534 created "2016-06-24" @default.
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- W2064607534 date "1997-02-01" @default.
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- W2064607534 title "The pathophysiology of persistent pulmonary hypertension of the newborn" @default.
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- W2064607534 doi "https://doi.org/10.1016/s1084-2756(97)80021-8" @default.
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