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- W2064621837 abstract "In Brief Background: The treatment of rheumatoid arthritis (RA) has changed dramatically over the past decade with the introduction of antitumor necrosis factor (anti-TNF) agents. Although subsets of patients may have only partial or no response, there is no report yet on possible worsening of RA with this therapy. Objective: The objective of this study was to determine whether infliximab may paradoxically exacerbate RA. Methods: One hundred seven patients with RA refractory to 3 disease-modifying antirheumatic drugs were treated with 3 mg/kg infliximab and methotrexate for at least 6 months. Results: In 3 patients, there was an exacerbation of RA associated with the use of infliximab. The flare occurred during the first 6 to 12 months of treatment with polyarthritis, fever, and elevated acute phase reactants. Increase of infliximab dose resulted in further deterioration. Conclusion: We describe a paradoxic reaction, an exacerbation of RA, with infliximab. The mechanism of this side effect is unclear but may be related to altered immunity induced by the inhibition of TNF activity in predisposed patients. Three of 107 patients treated with infliximab had dramatic worsening on treatment with one progressively deteriorating with increased doses. Might some rare patients respond adversely to inhibition of tumor necrosis factor?" @default.
- W2064621837 created "2016-06-24" @default.
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- W2064621837 date "2006-12-01" @default.
- W2064621837 modified "2023-10-18" @default.
- W2064621837 title "Polyarthritis Flare Complicating Rheumatoid Arthritis Infliximab Therapy" @default.
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- W2064621837 doi "https://doi.org/10.1097/01.rhu.0000250241.91842.b6" @default.
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