FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064642022> ?p ?o ?g. }

• W2064642022 endingPage "1571" @default.
• W2064642022 startingPage "1565" @default.
• W2064642022 abstract "We have examined the toxicity of trans-platinum (trans-diamminedichloroplatinum II) to heme and hemoprotein metabolism in the kidney of glutathione (GSH)-depleted rats and compared it with that produced by cis-platinum. Unlike cis-platinum treatment (7.0 mg/kg, i.v.) which caused after 7 days significant increases in cytochromes P450 and b5, and a marked decrease in porphyrin content of the kidney, trans-platinum alone (7 mg/kg, i.v.) did not elicit notable changes in these variables when measured 1 or 7 days after treatment. Also, cis-platinum treatment significantly altered the heme degradation pathway by increasing the activity of heme oxygenase and decreasing that of biliverdin reductase; trans-platinum treatment did not elicit a response in these activities. However, when rats were given the inhibitor of GSH synthesis, d,l-buthionine-S,R-sulfoximine (BSO), the subsequent administration (2 hr later) of trans-platinum produced, in 1 day, the spectrum of responses that were mediated by cis-platinum after 7 days. In the kidneys of rats treated with BSO plus trans-platinum the concentration of platinum measured only about 50% of that detected in the kidneys of rats treated with trans-platinum alone. In the liver, trans-platinum by itself or in combination with BSO was ineffective in altering the measured variables of heme metabolism. The possibility that similarity between cis- platinum and trans-platinum plus BSO may extend to systems other than heme metabolism, e.g. GSH synthesis and degradation, was examined. cis-Platinum caused significant inhibition of both renal γ-glutamyl synthetase and γ-glutamyl transpeptidase after 7 days, but not after 1 day. Twenty-four hours after treatment, BSO + trans-platinum caused inhibition of γ-glutamylcysteine synthetase activity, whereas this activity in animals treated with BSO alone had returned to control values. At this time point, neither oxidized glutathione (GSSG)-reductase nor γ-glutamyl transpeptidase activity was affected by trans-platinum + BSO treatment. The findings suggest that GSH constitutes an important defense mechanism against trans-platinum alteration of heme metabolism and may play a role in cellular accumulation of the drug in an inactive complex. It is proposed that BSO treatment, despite resulting in a diminished intracellular concentration of trans-platinum, allows reaction of the metal complex with target molecules by virtue of its ability to deplete GSH." @default.
• W2064642022 created "2016-06-24" @default.
• W2064642022 creator A5001051903 @default.
• W2064642022 creator A5060782788 @default.
• W2064642022 date "1990-05-01" @default.
• W2064642022 modified "2023-09-25" @default.
• W2064642022 title "Promotion of trans-platinum in vivo effects on renal heme and hemoprotein metabolism by d,l-buthionine-S,R-sulfoximine possible role of glutathione" @default.
• W2064642022 cites W1223981148 @default.
• W2064642022 cites W1497013369 @default.
• W2064642022 cites W1503187265 @default.
• W2064642022 cites W1512594715 @default.
• W2064642022 cites W1570910952 @default.
• W2064642022 cites W1591909631 @default.
• W2064642022 cites W1594872187 @default.
• W2064642022 cites W1775749144 @default.
• W2064642022 cites W1933537497 @default.
• W2064642022 cites W1949394866 @default.
• W2064642022 cites W1965098417 @default.
• W2064642022 cites W1970156619 @default.
• W2064642022 cites W1996838914 @default.
• W2064642022 cites W2012108057 @default.
• W2064642022 cites W2025457508 @default.
• W2064642022 cites W2026610836 @default.
• W2064642022 cites W2042440620 @default.
• W2064642022 cites W2044158166 @default.
• W2064642022 cites W2054002992 @default.
• W2064642022 cites W2060372099 @default.
• W2064642022 cites W2065101979 @default.
• W2064642022 cites W2075596731 @default.
• W2064642022 cites W2077884242 @default.
• W2064642022 cites W2091879279 @default.
• W2064642022 cites W2095074468 @default.
• W2064642022 cites W2132252055 @default.
• W2064642022 cites W2218041908 @default.
• W2064642022 cites W4252764622 @default.
• W2064642022 cites W8750466 @default.
• W2064642022 doi "https://doi.org/10.1016/0006-2952(90)90522-m" @default.
• W2064642022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2337413" @default.
• W2064642022 hasPublicationYear "1990" @default.
• W2064642022 type Work @default.
• W2064642022 sameAs 2064642022 @default.
• W2064642022 citedByCount "5" @default.
• W2064642022 countsByYear W20646420222013 @default.
• W2064642022 crossrefType "journal-article" @default.
• W2064642022 hasAuthorship W2064642022A5001051903 @default.
• W2064642022 hasAuthorship W2064642022A5060782788 @default.
• W2064642022 hasBestOaLocation W20646420221 @default.
• W2064642022 hasConcept C134018914 @default.
• W2064642022 hasConcept C161790260 @default.
• W2064642022 hasConcept C181199279 @default.
• W2064642022 hasConcept C185592680 @default.
• W2064642022 hasConcept C2776217839 @default.
• W2064642022 hasConcept C2777476445 @default.
• W2064642022 hasConcept C2779219270 @default.
• W2064642022 hasConcept C2779480358 @default.
• W2064642022 hasConcept C2780091579 @default.
• W2064642022 hasConcept C518104683 @default.
• W2064642022 hasConcept C538909803 @default.
• W2064642022 hasConcept C55493867 @default.
• W2064642022 hasConcept C62231903 @default.
• W2064642022 hasConcept C86803240 @default.
• W2064642022 hasConceptScore W2064642022C134018914 @default.
• W2064642022 hasConceptScore W2064642022C161790260 @default.
• W2064642022 hasConceptScore W2064642022C181199279 @default.
• W2064642022 hasConceptScore W2064642022C185592680 @default.
• W2064642022 hasConceptScore W2064642022C2776217839 @default.
• W2064642022 hasConceptScore W2064642022C2777476445 @default.
• W2064642022 hasConceptScore W2064642022C2779219270 @default.
• W2064642022 hasConceptScore W2064642022C2779480358 @default.
• W2064642022 hasConceptScore W2064642022C2780091579 @default.
• W2064642022 hasConceptScore W2064642022C518104683 @default.
• W2064642022 hasConceptScore W2064642022C538909803 @default.
• W2064642022 hasConceptScore W2064642022C55493867 @default.
• W2064642022 hasConceptScore W2064642022C62231903 @default.
• W2064642022 hasConceptScore W2064642022C86803240 @default.
• W2064642022 hasIssue "10" @default.
• W2064642022 hasLocation W20646420221 @default.
• W2064642022 hasLocation W20646420222 @default.
• W2064642022 hasOpenAccess W2064642022 @default.
• W2064642022 hasPrimaryLocation W20646420221 @default.
• W2064642022 hasRelatedWork W1978145359 @default.
• W2064642022 hasRelatedWork W1980173389 @default.
• W2064642022 hasRelatedWork W1984351917 @default.
• W2064642022 hasRelatedWork W1990392212 @default.
• W2064642022 hasRelatedWork W2027406668 @default.
• W2064642022 hasRelatedWork W2033775260 @default.
• W2064642022 hasRelatedWork W2064642022 @default.
• W2064642022 hasRelatedWork W2076014304 @default.
• W2064642022 hasRelatedWork W2090261508 @default.
• W2064642022 hasRelatedWork W2231406999 @default.
• W2064642022 hasVolume "39" @default.
• W2064642022 isParatext "false" @default.
• W2064642022 isRetracted "false" @default.
• W2064642022 magId "2064642022" @default.
• W2064642022 workType "article" @default.