Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064651856> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2064651856 endingPage "187" @default.
- W2064651856 startingPage "179" @default.
- W2064651856 abstract "Tetrahydroisoquinolines (TIQs) might be formed endogenously and can act centrally to promote a mechanism governing alcohol drinking behaviour. The possibility that biosynthesis occurs through a stereospecific enzymatic reaction is considered. Several TIQs were transformed into diastereomers by a two-step derivatization with N-methyl-N-trimethylsilyltrifluoracetamide and R-(−)-2-phenylbutyrylic acid and were analyzed by gas chromatography-mass spectrometry (GC-MS). High resolution of the TIQ enantiomers was achieved. This method was applied to the quantification of the enantiomers of salsolinol (SAL) in urine and plasma of healthy humans. Deuterated SAL was used as the internal standard. SAL was extracted from biological material using phenulboronic Deuterated SAL was used as the internal standard. SAL was extracted from biological material using phenylboronic phase cartridges and transformed into diastereomers. The sensitivity and specificity of the assay permit the determination of the enantiomeric composition of SAL in plasma and urine. The limit of quantification was found to be 100 pg/ml for each enantiomer. The described method has the advantage that optimal resolution of the SAL enantiomers without peak overlapping between analyte and other compounds can be achieved. Contrary to other findings, our GC-MS studies have demonstrated that endogenously formed SAL is racemic in plasma as well as in urine of healthy subjects." @default.
- W2064651856 created "2016-06-24" @default.
- W2064651856 creator A5016855923 @default.
- W2064651856 creator A5065064110 @default.
- W2064651856 creator A5068280143 @default.
- W2064651856 creator A5070199843 @default.
- W2064651856 date "1995-10-01" @default.
- W2064651856 modified "2023-09-27" @default.
- W2064651856 title "Resolution of catecholic tetrahydroisoquinoline enantiomers and the determination of R- and S-salsolinol in biological samples by gas chromatography-mass spectrometry" @default.
- W2064651856 cites W1982218524 @default.
- W2064651856 cites W1990361973 @default.
- W2064651856 cites W2011013374 @default.
- W2064651856 cites W2025839529 @default.
- W2064651856 cites W2031592965 @default.
- W2064651856 cites W2046851492 @default.
- W2064651856 cites W2049451030 @default.
- W2064651856 cites W2060907194 @default.
- W2064651856 cites W2063512635 @default.
- W2064651856 doi "https://doi.org/10.1016/0378-4347(95)00213-3" @default.
- W2064651856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8581123" @default.
- W2064651856 hasPublicationYear "1995" @default.
- W2064651856 type Work @default.
- W2064651856 sameAs 2064651856 @default.
- W2064651856 citedByCount "24" @default.
- W2064651856 countsByYear W20646518562012 @default.
- W2064651856 countsByYear W20646518562013 @default.
- W2064651856 countsByYear W20646518562014 @default.
- W2064651856 countsByYear W20646518562022 @default.
- W2064651856 crossrefType "journal-article" @default.
- W2064651856 hasAuthorship W2064651856A5016855923 @default.
- W2064651856 hasAuthorship W2064651856A5065064110 @default.
- W2064651856 hasAuthorship W2064651856A5068280143 @default.
- W2064651856 hasAuthorship W2064651856A5070199843 @default.
- W2064651856 hasConcept C10390740 @default.
- W2064651856 hasConcept C123460561 @default.
- W2064651856 hasConcept C138268822 @default.
- W2064651856 hasConcept C138716334 @default.
- W2064651856 hasConcept C154945302 @default.
- W2064651856 hasConcept C162356407 @default.
- W2064651856 hasConcept C185592680 @default.
- W2064651856 hasConcept C205345274 @default.
- W2064651856 hasConcept C2776923573 @default.
- W2064651856 hasConcept C41008148 @default.
- W2064651856 hasConcept C43617362 @default.
- W2064651856 hasConcept C486523 @default.
- W2064651856 hasConcept C71240020 @default.
- W2064651856 hasConceptScore W2064651856C10390740 @default.
- W2064651856 hasConceptScore W2064651856C123460561 @default.
- W2064651856 hasConceptScore W2064651856C138268822 @default.
- W2064651856 hasConceptScore W2064651856C138716334 @default.
- W2064651856 hasConceptScore W2064651856C154945302 @default.
- W2064651856 hasConceptScore W2064651856C162356407 @default.
- W2064651856 hasConceptScore W2064651856C185592680 @default.
- W2064651856 hasConceptScore W2064651856C205345274 @default.
- W2064651856 hasConceptScore W2064651856C2776923573 @default.
- W2064651856 hasConceptScore W2064651856C41008148 @default.
- W2064651856 hasConceptScore W2064651856C43617362 @default.
- W2064651856 hasConceptScore W2064651856C486523 @default.
- W2064651856 hasConceptScore W2064651856C71240020 @default.
- W2064651856 hasIssue "2" @default.
- W2064651856 hasLocation W20646518561 @default.
- W2064651856 hasLocation W20646518562 @default.
- W2064651856 hasOpenAccess W2064651856 @default.
- W2064651856 hasPrimaryLocation W20646518561 @default.
- W2064651856 hasRelatedWork W1501327152 @default.
- W2064651856 hasRelatedWork W1984872425 @default.
- W2064651856 hasRelatedWork W1994642341 @default.
- W2064651856 hasRelatedWork W2013888808 @default.
- W2064651856 hasRelatedWork W2027787998 @default.
- W2064651856 hasRelatedWork W2059060210 @default.
- W2064651856 hasRelatedWork W2059485640 @default.
- W2064651856 hasRelatedWork W2079522539 @default.
- W2064651856 hasRelatedWork W2149258094 @default.
- W2064651856 hasRelatedWork W3046579356 @default.
- W2064651856 hasVolume "672" @default.
- W2064651856 isParatext "false" @default.
- W2064651856 isRetracted "false" @default.
- W2064651856 magId "2064651856" @default.
- W2064651856 workType "article" @default.