FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064658478> ?p ?o ?g. }

• W2064658478 endingPage "41" @default.
• W2064658478 startingPage "36" @default.
• W2064658478 abstract "Background There are few experimental models of heart failure (HF) in large animals, despite structural and functional similarities to human myocardium. We have developed a porcine model of chronic tachycardia-induced cardiomyopathy. Methods Homogenous siblings of White Large breed swine (n=6) underwent continuous right ventricular (RV) pacing at 170 bpm; 2 subjects served as controls. In the course of RV pacing, animals developed a clinical picture of HF and were presented for euthanasia at subsequent stages: mild, moderate and end-stage HF. Left ventricle (LV) sections were analyzed histologically and relative ANP, BNP, phospholamban and sarcoplasmic reticulum calcium ATPase 2a transcript levels in LV were quantified by real time RT-PCR. Results In the course of RV pacing, animals demonstrated reduced exercise capacity (time of running until being dyspnoeic: 6.6±0.5 vs. 2.4±1.4 min), LV dilatation (LVEDD: 4.9±0.4 vs. 6.7±0.4 cm), impaired LV systolic function (LVEF: 69±8 vs. 32±7 %), (all baseline vs. before euthanasia, all p<0.001). LV tissues from animals with moderate and end-stage HF demonstrated local foci of interstitial fibrosis, congestion, cardiomyocyte hypertrophy and atrophy, which was not detected in controls and mild HF animals. The up-regulation of ANP and BNP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a and phospholamban in failing myocardium were observed as compared to controls. Conclusions In pigs, chronic RV pacing at relatively low rate can be used as an experimental model of HF, as it results in a gradual deterioration of exercise tolerance accompanied by myocardial remodeling confirmed at subcellular level." @default.
• W2064658478 created "2016-06-24" @default.
• W2064658478 creator A5001275622 @default.
• W2064658478 creator A5011941530 @default.
• W2064658478 creator A5014093784 @default.
• W2064658478 creator A5015401708 @default.
• W2064658478 creator A5016346416 @default.
• W2064658478 creator A5017272571 @default.
• W2064658478 creator A5045812312 @default.
• W2064658478 creator A5052389517 @default.
• W2064658478 creator A5060696308 @default.
• W2064658478 creator A5071401700 @default.
• W2064658478 creator A5071789037 @default.
• W2064658478 creator A5072613576 @default.
• W2064658478 creator A5073994077 @default.
• W2064658478 creator A5081060061 @default.
• W2064658478 date "2011-11-01" @default.
• W2064658478 modified "2023-09-30" @default.
• W2064658478 title "Development of porcine model of chronic tachycardia-induced cardiomyopathy" @default.
• W2064658478 cites W1480526824 @default.
• W2064658478 cites W1540954219 @default.
• W2064658478 cites W1600309003 @default.
• W2064658478 cites W1895665623 @default.
• W2064658478 cites W1971903226 @default.
• W2064658478 cites W1988072219 @default.
• W2064658478 cites W1988710835 @default.
• W2064658478 cites W2009950005 @default.
• W2064658478 cites W2031161073 @default.
• W2064658478 cites W2044240014 @default.
• W2064658478 cites W2052780003 @default.
• W2064658478 cites W2060079534 @default.
• W2064658478 cites W2061468454 @default.
• W2064658478 cites W2075151081 @default.
• W2064658478 cites W2081347317 @default.
• W2064658478 cites W2084291244 @default.
• W2064658478 cites W2086999698 @default.
• W2064658478 cites W2095035381 @default.
• W2064658478 cites W2099249565 @default.
• W2064658478 cites W2103900382 @default.
• W2064658478 cites W2116035231 @default.
• W2064658478 cites W2135287165 @default.
• W2064658478 cites W2141573806 @default.
• W2064658478 cites W2148338214 @default.
• W2064658478 cites W2153371528 @default.
• W2064658478 cites W2164160223 @default.
• W2064658478 cites W2165415846 @default.
• W2064658478 cites W2170045306 @default.
• W2064658478 cites W2171137042 @default.
• W2064658478 cites W2547318251 @default.
• W2064658478 cites W4255009698 @default.
• W2064658478 doi "https://doi.org/10.1016/j.ijcard.2010.08.033" @default.
• W2064658478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20880599" @default.
• W2064658478 hasPublicationYear "2011" @default.
• W2064658478 type Work @default.
• W2064658478 sameAs 2064658478 @default.
• W2064658478 citedByCount "18" @default.
• W2064658478 countsByYear W20646584782013 @default.
• W2064658478 countsByYear W20646584782014 @default.
• W2064658478 countsByYear W20646584782015 @default.
• W2064658478 countsByYear W20646584782016 @default.
• W2064658478 countsByYear W20646584782019 @default.
• W2064658478 countsByYear W20646584782021 @default.
• W2064658478 countsByYear W20646584782022 @default.
• W2064658478 crossrefType "journal-article" @default.
• W2064658478 hasAuthorship W2064658478A5001275622 @default.
• W2064658478 hasAuthorship W2064658478A5011941530 @default.
• W2064658478 hasAuthorship W2064658478A5014093784 @default.
• W2064658478 hasAuthorship W2064658478A5015401708 @default.
• W2064658478 hasAuthorship W2064658478A5016346416 @default.
• W2064658478 hasAuthorship W2064658478A5017272571 @default.
• W2064658478 hasAuthorship W2064658478A5045812312 @default.
• W2064658478 hasAuthorship W2064658478A5052389517 @default.
• W2064658478 hasAuthorship W2064658478A5060696308 @default.
• W2064658478 hasAuthorship W2064658478A5071401700 @default.
• W2064658478 hasAuthorship W2064658478A5071789037 @default.
• W2064658478 hasAuthorship W2064658478A5072613576 @default.
• W2064658478 hasAuthorship W2064658478A5073994077 @default.
• W2064658478 hasAuthorship W2064658478A5081060061 @default.
• W2064658478 hasConcept C126322002 @default.
• W2064658478 hasConcept C134018914 @default.
• W2064658478 hasConcept C164705383 @default.
• W2064658478 hasConcept C167414201 @default.
• W2064658478 hasConcept C17137333 @default.
• W2064658478 hasConcept C2778198053 @default.
• W2064658478 hasConcept C2778797674 @default.
• W2064658478 hasConcept C2778921608 @default.
• W2064658478 hasConcept C2780283014 @default.
• W2064658478 hasConcept C2780559512 @default.
• W2064658478 hasConcept C71924100 @default.
• W2064658478 hasConcept C78085059 @default.
• W2064658478 hasConceptScore W2064658478C126322002 @default.
• W2064658478 hasConceptScore W2064658478C134018914 @default.
• W2064658478 hasConceptScore W2064658478C164705383 @default.
• W2064658478 hasConceptScore W2064658478C167414201 @default.
• W2064658478 hasConceptScore W2064658478C17137333 @default.
• W2064658478 hasConceptScore W2064658478C2778198053 @default.
• W2064658478 hasConceptScore W2064658478C2778797674 @default.
• W2064658478 hasConceptScore W2064658478C2778921608 @default.

• next