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- W2064666404 abstract "We previously reported that immunoreactive corticotropin-releasing hormone (CRH) is present in human placenta and third trimester maternal plasma, and that such material is very similar to rat CRH and the predicted structure of human CRH. We suggested that maternal plasma immunoreactive CRH may be of placental origin. To further investigate this possibility, we measured plasma immunoreactive CRH in women during pregnancy, labor, and delivery and 1 and 2 h postpartum, and in nonpregnant women. Umbilical cord plasma and placental CRH concentrations were also measured. In the first trimester of pregnancy, the mean maternal plasma level was 5.9 ± 1.0 pg (±sem)/ml (n = 24), not significantly different from that in 10 nonpregnant women (5.8 ± 0.8 pg/ml). Plasma CRH concentrations progressively increased during pregnancy (second trimester, 35.4 ± 5.9 pg/ml (n = 39); early third trimester (28–34 weeks), 263 ± 41 pg/ml (n = 14); late third trimester (35-40 weeks), 800 ± 163 pg/ml (n = 20)]. There was a significant correlation between maternal plasma CRH levels and weeks of pregnancy. Plasma CRH concentrations were further elevated (2215 ± 329 pg/ml; n = 9). During early labor, peaked at delivery (4409 ± 591 pg/ml; n = 28), and declined rapidly after delivery [1 h postpartum, 1042 ± (353 pg/ml (n = 13); 2 h postpartum, 346 ± 91 pg/ml (n = 13)]. There was a significant correlation (r = 0.562; P < 0.01) between matched maternal plasma and placental CRH concentrations. The mean umbilical cord plasma CRH level (50.6 ±6.1 pg/ml; n = 28) was much lower than that in the mother at the time of delivery. Umbilical venous plasma CRH levels were significantly greater than those in simultaneously obtained umbilical arterial plasma (70.8 ± 11.3 and 41.8 ± 4.9 pg/ml, respectively; n = 11). There was a significant correlation (r = 0.384; P < 0.05) between maternal and fetal CRH concentrations. Gel filtration of plasma obtained from women during the third trimester, at delivery, and early postpartum and placental extracts revealed two major peaks of immunoreactive CRH: a high mol wt peak and one at the elution position of rat CRH. In contrast, only rat CRH-sized material was detected in plasma from nonpregnant women and umbilical cord plasma. Maternal plasma immunoreactive CRH-sized material stimulated ACTH release from anterior pituitary tissue in a dosedependent manner and was equipotent with rat CRH. These results suggest that biologically active CRH of placental origin may be preferentially secreted into the maternal circulation and provide an extrahypothalamic stimulatory input to the maternal anterior pituitary. Placental CRH may be an important stimulator of the maternal pituitary-adrenal axis during pregnancy, labor, and delivery." @default.
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- W2064666404 date "1987-02-01" @default.
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- W2064666404 title "Immunoreactive Corticotropin-Releasing Hormone in Human Plasma During Pregnancy, Labor, and Delivery*" @default.
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- W2064666404 doi "https://doi.org/10.1210/jcem-64-2-224" @default.
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