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• W2064669907 abstract "We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV." @default.
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• W2064669907 date "2000-12-01" @default.
• W2064669907 modified "2023-09-26" @default.
• W2064669907 title "Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7" @default.
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• W2064669907 doi "https://doi.org/10.1016/s0140-6736(00)03315-8" @default.
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