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- W2064676235 abstract "To the Editor: We were very interested to find that Laser et al. found >50% cellular senescence in 11% of their leiomyomata (1Laser J. Lee P. Wei J.-J. Cellular senescence in usual type uterine leiomyoma.Fertil Steril. 2010; 93: 2020-2026Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar), similar to the 7% of tumors in the National Institute of Environmental Health Sciences (NIEHS) Fibroid Growth Study that were found to be rapidly shrinking (2Peddada S.D. Laughlin S.K. Miner K. Guyon J.P. Haneke K. Vahdat H.L. et al.Growth of uterine leiomyomata among premenopausal black and white women.Proc Natl Acad Sci USA. 2008; 105: 19887-19892Crossref PubMed Scopus (235) Google Scholar). We were particularly interested in the finding of increased senescence with age. We reported lower fibroid growth rates with age in tumors from the NIEHS Fibroid Growth Study, but only for white women (2Peddada S.D. Laughlin S.K. Miner K. Guyon J.P. Haneke K. Vahdat H.L. et al.Growth of uterine leiomyomata among premenopausal black and white women.Proc Natl Acad Sci USA. 2008; 105: 19887-19892Crossref PubMed Scopus (235) Google Scholar). Age was not associated with tumor growth rates in tumors from black women. We recognize that numbers are small, but was there any suggestion of a difference between blacks and others in the pattern of age-related senescence for the 86 tumors in the Laser et al. analysis? Cellular senescence in usual type uterine leiomyomaFertility and SterilityVol. 93Issue 6PreviewTo evaluate the role of senescence in symptomatic patients with multifibroids. Full-Text PDF Reply of the Authors: Cellular senescence in usual type uterine leiomyomaFertility and SterilityVol. 94Issue 2PreviewWe thank Drs. Baird, Davis, and Peddada for sharing their findings of the natural history for fibroid growth in association with age and ethnicity (1). Since racial disparity for fibroid growth is a very interesting topic, it deserves another look for racial differences in cellular senescence. Full-Text PDF" @default.
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- W2064676235 date "2010-07-01" @default.
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- W2064676235 title "Cellular senescence in usual type uterine leiomyoma" @default.
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- W2064676235 doi "https://doi.org/10.1016/j.fertnstert.2010.04.068" @default.
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