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- W2064686723 abstract "Purpose of review Letrozole, an aromatase inhibitor, is the newest addition to our armamentarium in the treatment of infertility. It is utilized in much the same way as clomiphene citrate, but with some additional benefits. In this review, the latest studies will be summarized with emphasis on dose, duration of use, safety, number of mature follicles, and pregnancy outcomes. Recent findings Letrozole has fewer side effects, and a shorter half-life than clomiphene citrate, and no demonstrable effect upon the receptivity of the endometrium. It is efficacious in treating women with chronic anovulation, unexplained infertility and diminished ovarian reserve. Its safety is superior to clomiphene citrate. Utilizing bio-equivalent doses, letrozole pregnancy rates are equal or superior to clomiphene citrate. Several studies suggest situations where it is more efficacious than gonadotropin treatment. Summary With further study, this drug could replace clomiphene citrate as the primary medication for chronic anovulation and/or unexplained infertility. It could augment or even obviate the use of gonadotropins in the treatment of women who have been unsuccessful in achieving pregnancy with clomiphene citrate. It may also be an adjunct for women with diminished ovarian reserve. Further studies are needed to determine optimal dosing and long term safety for women treated with the drug." @default.
- W2064686723 created "2016-06-24" @default.
- W2064686723 creator A5009224959 @default.
- W2064686723 date "2010-08-01" @default.
- W2064686723 modified "2023-10-16" @default.
- W2064686723 title "Letrozole for ovulation induction and controlled ovarian hyperstimulation" @default.
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- W2064686723 doi "https://doi.org/10.1097/gco.0b013e32833beebf" @default.
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