FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064687673> ?p ?o ?g. }

• W2064687673 abstract "Tetrodotoxin-sensitive (TTXS) sodium currents in dorsal root ganglia (DRG) neurons were enhanced by DcAMP applied acutely or by pre-treatment. Pre-treatment increased peak TTXS by 28%. This compared to the increase of tetrodotoxin-resistant sodium currents (TTXR) of 123%. In both cases the increase was associated with a hyperpolarizing shift in activation potentials. Slow inactivation was slower for both TTXR and TTXS in DcAMP treated neurons but rates of recovery from inactivation were not altered. Lidocaine blocked TTX-R with an IC(50) of 0.51+/-0.15mM (n=9) which was reduced to 0.14+/-0.05mM (n=8, P<0.05) in DcAMP treated cells. The sensitivity of TTX-S currents to lidocaine was not altered by DcAMP (control EC(50)=0.89+/-0.16mM, n=9; DcAMP EC(50)=0.73+/-0.19mM, n=6). It is concluded that TTXS currents in DRG are, like TTX-R currents, enhanced by cAMP but whilst the pharmacology of TTXR channels with respect to lidocaine is altered, that to TTXS channels is not." @default.
• W2064687673 created "2016-06-24" @default.
• W2064687673 creator A5054766027 @default.
• W2064687673 creator A5065974322 @default.
• W2064687673 date "2006-11-01" @default.
• W2064687673 modified "2023-09-27" @default.
• W2064687673 title "The effect of dibutyryl cAMP on tetrodotoxin-sensitive and -resistant voltage-gated sodium currents in rat dorsal root ganglion neurons and the consequences for their sensitivity to lidocaine" @default.
• W2064687673 cites W1583934186 @default.
• W2064687673 cites W1849803462 @default.
• W2064687673 cites W1978939719 @default.
• W2064687673 cites W1986849239 @default.
• W2064687673 cites W1990523804 @default.
• W2064687673 cites W1992381754 @default.
• W2064687673 cites W1993584057 @default.
• W2064687673 cites W1994011917 @default.
• W2064687673 cites W1994094702 @default.
• W2064687673 cites W1995100344 @default.
• W2064687673 cites W2000574545 @default.
• W2064687673 cites W2000702493 @default.
• W2064687673 cites W2004413159 @default.
• W2064687673 cites W2013173477 @default.
• W2064687673 cites W2013947622 @default.
• W2064687673 cites W2022050392 @default.
• W2064687673 cites W2024496524 @default.
• W2064687673 cites W2036241034 @default.
• W2064687673 cites W2037170098 @default.
• W2064687673 cites W2039072874 @default.
• W2064687673 cites W2048656464 @default.
• W2064687673 cites W2050577224 @default.
• W2064687673 cites W2070390515 @default.
• W2064687673 cites W2085018934 @default.
• W2064687673 cites W2091746433 @default.
• W2064687673 cites W2100977258 @default.
• W2064687673 cites W2105172736 @default.
• W2064687673 cites W2105493663 @default.
• W2064687673 cites W2134321467 @default.
• W2064687673 cites W2140542147 @default.
• W2064687673 cites W2147142375 @default.
• W2064687673 cites W2169064772 @default.
• W2064687673 cites W2192754709 @default.
• W2064687673 cites W2342002801 @default.
• W2064687673 cites W1904081746 @default.
• W2064687673 doi "https://doi.org/10.1016/j.neuropharm.2006.06.021" @default.
• W2064687673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16930635" @default.
• W2064687673 hasPublicationYear "2006" @default.
• W2064687673 type Work @default.
• W2064687673 sameAs 2064687673 @default.
• W2064687673 citedByCount "9" @default.
• W2064687673 countsByYear W20646876732012 @default.
• W2064687673 countsByYear W20646876732018 @default.
• W2064687673 countsByYear W20646876732021 @default.
• W2064687673 crossrefType "journal-article" @default.
• W2064687673 hasAuthorship W2064687673A5054766027 @default.
• W2064687673 hasAuthorship W2064687673A5065974322 @default.
• W2064687673 hasConcept C105702510 @default.
• W2064687673 hasConcept C12554922 @default.
• W2064687673 hasConcept C126322002 @default.
• W2064687673 hasConcept C134018914 @default.
• W2064687673 hasConcept C140530291 @default.
• W2064687673 hasConcept C169760540 @default.
• W2064687673 hasConcept C178790620 @default.
• W2064687673 hasConcept C185592680 @default.
• W2064687673 hasConcept C2776281502 @default.
• W2064687673 hasConcept C2776741303 @default.
• W2064687673 hasConcept C2780149897 @default.
• W2064687673 hasConcept C42219234 @default.
• W2064687673 hasConcept C50952357 @default.
• W2064687673 hasConcept C537181965 @default.
• W2064687673 hasConcept C71924100 @default.
• W2064687673 hasConcept C86803240 @default.
• W2064687673 hasConcept C98274493 @default.
• W2064687673 hasConceptScore W2064687673C105702510 @default.
• W2064687673 hasConceptScore W2064687673C12554922 @default.
• W2064687673 hasConceptScore W2064687673C126322002 @default.
• W2064687673 hasConceptScore W2064687673C134018914 @default.
• W2064687673 hasConceptScore W2064687673C140530291 @default.
• W2064687673 hasConceptScore W2064687673C169760540 @default.
• W2064687673 hasConceptScore W2064687673C178790620 @default.
• W2064687673 hasConceptScore W2064687673C185592680 @default.
• W2064687673 hasConceptScore W2064687673C2776281502 @default.
• W2064687673 hasConceptScore W2064687673C2776741303 @default.
• W2064687673 hasConceptScore W2064687673C2780149897 @default.
• W2064687673 hasConceptScore W2064687673C42219234 @default.
• W2064687673 hasConceptScore W2064687673C50952357 @default.
• W2064687673 hasConceptScore W2064687673C537181965 @default.
• W2064687673 hasConceptScore W2064687673C71924100 @default.
• W2064687673 hasConceptScore W2064687673C86803240 @default.
• W2064687673 hasConceptScore W2064687673C98274493 @default.
• W2064687673 hasLocation W20646876731 @default.
• W2064687673 hasLocation W20646876732 @default.
• W2064687673 hasOpenAccess W2064687673 @default.
• W2064687673 hasPrimaryLocation W20646876731 @default.
• W2064687673 hasRelatedWork W1968530210 @default.
• W2064687673 hasRelatedWork W1990019804 @default.
• W2064687673 hasRelatedWork W1993462384 @default.
• W2064687673 hasRelatedWork W2005108928 @default.
• W2064687673 hasRelatedWork W2061904925 @default.
• W2064687673 hasRelatedWork W2064687673 @default.
• W2064687673 hasRelatedWork W2070676751 @default.
• W2064687673 hasRelatedWork W2123369785 @default.

• next