FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064692208> ?p ?o ?g. }

• W2064692208 endingPage "502" @default.
• W2064692208 startingPage "496" @default.
• W2064692208 abstract "Human dendritic cells (DCs) play an important role in induction and progression of Crohn's disease (CD). Accumulating evidence suggests that viral infection is required to trigger CD pathogenesis in genetically predisposed individuals. NOD2 and ATG16L1 are among the major CD susceptibility genes implicated in impaired immune response to bacterial infection. In this study, we investigated gene expression and allelic imbalance (AI) of NOD2 and ATG16L1 using common variants in human monocyte-derived DCs. Significant AI was observed in ~ 40% and ~ 70% of NOD2 and ATG16L1 heterozygotes, respectively (p < 0.05). AI of NOD2 was inversely associated with its expression level (p = 0.015). No correlation was detected between gene expression and AI for ATG16L1. When infected with Newcastle Disease Virus (NDV), NOD2 expression in DCs was induced about four-fold (p < 0.001), whereas ATG16L1 expression was not affected (p = 0.88). In addition, NDV infection tended to lower the variance in AI among DC populations for the NOD2 gene (p = 0.05), but not the ATG16L1 gene (p = 0.32). Findings of a simulation study, aimed to verify whether the observed variation in gene expression and AI is a result of sample-to-sample variability or experimental measurement error, suggested that NOD2 AI is likely to result from a deterministic event at a single cell level. Overall, our results present initial evidence that AI of the NOD2 and ATG16L1 genes exists in populations of human DCs. In addition, our findings suggest that viral infection may regulate NOD2 expression." @default.
• W2064692208 created "2016-06-24" @default.
• W2064692208 creator A5050508468 @default.
• W2064692208 creator A5063878749 @default.
• W2064692208 date "2013-09-01" @default.
• W2064692208 modified "2023-09-23" @default.
• W2064692208 title "Evidence of expression variation and allelic imbalance in Crohn's disease susceptibility genes NOD2 and ATG16L1 in human dendritic cells" @default.
• W2064692208 cites W1581081864 @default.
• W2064692208 cites W1971046821 @default.
• W2064692208 cites W1982789154 @default.
• W2064692208 cites W1983625329 @default.
• W2064692208 cites W1984127959 @default.
• W2064692208 cites W1986497531 @default.
• W2064692208 cites W1998554580 @default.
• W2064692208 cites W2009680012 @default.
• W2064692208 cites W2011197968 @default.
• W2064692208 cites W2025184453 @default.
• W2064692208 cites W2028536701 @default.
• W2064692208 cites W2032262423 @default.
• W2064692208 cites W2033877575 @default.
• W2064692208 cites W2046819049 @default.
• W2064692208 cites W2052435488 @default.
• W2064692208 cites W2057610674 @default.
• W2064692208 cites W2059133930 @default.
• W2064692208 cites W2059566143 @default.
• W2064692208 cites W2064741210 @default.
• W2064692208 cites W2072743939 @default.
• W2064692208 cites W2081026727 @default.
• W2064692208 cites W2084708009 @default.
• W2064692208 cites W2086938034 @default.
• W2064692208 cites W2096853390 @default.
• W2064692208 cites W2106070528 @default.
• W2064692208 cites W2111220263 @default.
• W2064692208 cites W2118737448 @default.
• W2064692208 cites W2119708638 @default.
• W2064692208 cites W2122031852 @default.
• W2064692208 cites W2127605828 @default.
• W2064692208 cites W2128476271 @default.
• W2064692208 cites W2130365449 @default.
• W2064692208 cites W2133006561 @default.
• W2064692208 cites W2134898472 @default.
• W2064692208 cites W2142642738 @default.
• W2064692208 cites W2143625465 @default.
• W2064692208 cites W2146496695 @default.
• W2064692208 cites W2152714853 @default.
• W2064692208 cites W2157255740 @default.
• W2064692208 cites W2159797569 @default.
• W2064692208 cites W2165541556 @default.
• W2064692208 cites W2171005514 @default.
• W2064692208 cites W4237269866 @default.
• W2064692208 cites W4244626580 @default.
• W2064692208 doi "https://doi.org/10.1016/j.gene.2013.06.066" @default.
• W2064692208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4135475" @default.
• W2064692208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23850724" @default.
• W2064692208 hasPublicationYear "2013" @default.
• W2064692208 type Work @default.
• W2064692208 sameAs 2064692208 @default.
• W2064692208 citedByCount "5" @default.
• W2064692208 countsByYear W20646922082017 @default.
• W2064692208 countsByYear W20646922082020 @default.
• W2064692208 countsByYear W20646922082022 @default.
• W2064692208 crossrefType "journal-article" @default.
• W2064692208 hasAuthorship W2064692208A5050508468 @default.
• W2064692208 hasAuthorship W2064692208A5063878749 @default.
• W2064692208 hasBestOaLocation W20646922082 @default.
• W2064692208 hasConcept C104317684 @default.
• W2064692208 hasConcept C136449434 @default.
• W2064692208 hasConcept C150194340 @default.
• W2064692208 hasConcept C153471976 @default.
• W2064692208 hasConcept C180754005 @default.
• W2064692208 hasConcept C187092789 @default.
• W2064692208 hasConcept C190283241 @default.
• W2064692208 hasConcept C203014093 @default.
• W2064692208 hasConcept C203522944 @default.
• W2064692208 hasConcept C54355233 @default.
• W2064692208 hasConcept C7573103 @default.
• W2064692208 hasConcept C86803240 @default.
• W2064692208 hasConcept C8891405 @default.
• W2064692208 hasConceptScore W2064692208C104317684 @default.
• W2064692208 hasConceptScore W2064692208C136449434 @default.
• W2064692208 hasConceptScore W2064692208C150194340 @default.
• W2064692208 hasConceptScore W2064692208C153471976 @default.
• W2064692208 hasConceptScore W2064692208C180754005 @default.
• W2064692208 hasConceptScore W2064692208C187092789 @default.
• W2064692208 hasConceptScore W2064692208C190283241 @default.
• W2064692208 hasConceptScore W2064692208C203014093 @default.
• W2064692208 hasConceptScore W2064692208C203522944 @default.
• W2064692208 hasConceptScore W2064692208C54355233 @default.
• W2064692208 hasConceptScore W2064692208C7573103 @default.
• W2064692208 hasConceptScore W2064692208C86803240 @default.
• W2064692208 hasConceptScore W2064692208C8891405 @default.
• W2064692208 hasIssue "2" @default.
• W2064692208 hasLocation W20646922081 @default.
• W2064692208 hasLocation W20646922082 @default.
• W2064692208 hasLocation W20646922083 @default.
• W2064692208 hasLocation W20646922084 @default.
• W2064692208 hasOpenAccess W2064692208 @default.
• W2064692208 hasPrimaryLocation W20646922081 @default.

• next