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- W2064693788 abstract "To test the hypothesis that plasminogen activator inhibitor‐1 (PAI‐1) may serve as a candidate marker for the malignancy of gastric cancer, we carried out quantitative reverse transcription–polymerase chain reaction for the PAI‐1 gene and evaluated the possible relationship between PAI‐1 gene expression levels and clinicopathological findings in gastric cancer. A significant increase in PAI‐1 expression scores was observed in lymph node metastasis‐positive gastric cancers (2.11 ± 0.35) compared to metastasis‐negative cancers (0.33 ± 0.49) ( P = 0.0048), as well as in distant metastasis‐positive gastric cancers (3.68 ± 0.58) compared to metastasis‐negative cancers (1.20 ± 0.32). The PAI‐1 expression score markedly increased with tumor stage ( P < 0.0001; ANOVA test). Moreover, multivariate analysis revealed the PAI‐1 expression score to be a strong and independent prognostic factor for gastric cancer ( P = 0.0450). These results suggested that PAI‐1 might serve as a new and promising parameter for the prediction of prognosis in gastric cancer. ( Cancer Sci 2006; 97)" @default.
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- W2064693788 date "2006-03-13" @default.
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- W2064693788 title "Plasminogen activator inhibitor-1 as a potential marker for the malignancy of gastric cancer" @default.
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- W2064693788 doi "https://doi.org/10.1111/j.1349-7006.2006.00185.x" @default.
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