FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064695746> ?p ?o ?g. }

• W2064695746 endingPage "59" @default.
• W2064695746 startingPage "52" @default.
• W2064695746 abstract "DW-116 is a newly developed fluoroquinolone antibacterial with a broad spectrum against both Gram-positive and Gram-negative bacteria. We have reported recently that DW-116 is embryotoxic and teratogenic in rats. The present study was conducted to investigate the teratogenicity of DW-116, together with maternal toxicity and developmental toxicity using New Zealand White rabbits. The test chemical was administered by gavage to pregnant rabbits from gestational day (GD) 6 through to GD 18 at dose levels of 0, 5, 19.5 and 76.1 mg kg(-1) day(-1). All does were subjected to caesarean section on day 28 of gestation and their foetuses were examined for external, visceral and skeletal abnormalities. In the 76.1 mg kg(-1) group, a minimal maternal toxicity, as evidenced by decreased body weight gain during treatment period, was observed in pregnant rabbits. Significant embryo-foetal toxicity, including increased number of foetal deaths and delayed foetal ossification, was seen. However, no treatment-related morphological changes were detected in foetal external, visceral and skeletal examinations. There were no adverse effects on either pregnant dams or embryo-foetal development at 19.5 and 5 mg kg(-1). It was concluded that administration of DW-116 during the major organogenetic period in rabbits produced decreased maternal body weight gain, increased number of foetal deaths and foetal developmental delay but no evidence of teratogenicity. The no-observed-adverse-effect levels (NOAELs) of DW-116 are considered to be 19.5 mg kg(-1) day(-1) for does and embryo-foetuses, respectively." @default.
• W2064695746 created "2016-06-24" @default.
• W2064695746 creator A5011750898 @default.
• W2064695746 creator A5025718651 @default.
• W2064695746 creator A5031785128 @default.
• W2064695746 creator A5034420128 @default.
• W2064695746 creator A5038956457 @default.
• W2064695746 creator A5048481601 @default.
• W2064695746 creator A5050918797 @default.
• W2064695746 creator A5066769533 @default.
• W2064695746 date "2005-01-01" @default.
• W2064695746 modified "2023-10-12" @default.
• W2064695746 title "Developmental toxicity assessment of the new ?uoroquinolone antibacterial DW-116 in rabbits" @default.
• W2064695746 cites W192550726 @default.
• W2064695746 cites W1972162864 @default.
• W2064695746 cites W1977228369 @default.
• W2064695746 cites W1989507711 @default.
• W2064695746 cites W1996920188 @default.
• W2064695746 cites W2001416733 @default.
• W2064695746 cites W2025642282 @default.
• W2064695746 cites W2031004115 @default.
• W2064695746 cites W2034847796 @default.
• W2064695746 cites W2035247087 @default.
• W2064695746 cites W2045742866 @default.
• W2064695746 cites W2047641456 @default.
• W2064695746 cites W2048932154 @default.
• W2064695746 cites W2050782027 @default.
• W2064695746 cites W2054953822 @default.
• W2064695746 cites W2069320524 @default.
• W2064695746 cites W2089087883 @default.
• W2064695746 cites W2093627649 @default.
• W2064695746 cites W2110346391 @default.
• W2064695746 cites W2136561870 @default.
• W2064695746 cites W2141901968 @default.
• W2064695746 cites W2148865886 @default.
• W2064695746 cites W2153384013 @default.
• W2064695746 cites W2197227471 @default.
• W2064695746 cites W2319438985 @default.
• W2064695746 cites W2326986812 @default.
• W2064695746 cites W2414492623 @default.
• W2064695746 cites W4251096219 @default.
• W2064695746 doi "https://doi.org/10.1002/jat.1033" @default.
• W2064695746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15669036" @default.
• W2064695746 hasPublicationYear "2005" @default.
• W2064695746 type Work @default.
• W2064695746 sameAs 2064695746 @default.
• W2064695746 citedByCount "6" @default.
• W2064695746 countsByYear W20646957462014 @default.
• W2064695746 crossrefType "journal-article" @default.
• W2064695746 hasAuthorship W2064695746A5011750898 @default.
• W2064695746 hasAuthorship W2064695746A5025718651 @default.
• W2064695746 hasAuthorship W2064695746A5031785128 @default.
• W2064695746 hasAuthorship W2064695746A5034420128 @default.
• W2064695746 hasAuthorship W2064695746A5038956457 @default.
• W2064695746 hasAuthorship W2064695746A5048481601 @default.
• W2064695746 hasAuthorship W2064695746A5050918797 @default.
• W2064695746 hasAuthorship W2064695746A5066769533 @default.
• W2064695746 hasConcept C126322002 @default.
• W2064695746 hasConcept C147583825 @default.
• W2064695746 hasConcept C172680121 @default.
• W2064695746 hasConcept C179335377 @default.
• W2064695746 hasConcept C196843134 @default.
• W2064695746 hasConcept C197934379 @default.
• W2064695746 hasConcept C2779234561 @default.
• W2064695746 hasConcept C2780320433 @default.
• W2064695746 hasConcept C29730261 @default.
• W2064695746 hasConcept C42407357 @default.
• W2064695746 hasConcept C46973012 @default.
• W2064695746 hasConcept C54355233 @default.
• W2064695746 hasConcept C65290608 @default.
• W2064695746 hasConcept C71924100 @default.
• W2064695746 hasConcept C86803240 @default.
• W2064695746 hasConcept C95444343 @default.
• W2064695746 hasConceptScore W2064695746C126322002 @default.
• W2064695746 hasConceptScore W2064695746C147583825 @default.
• W2064695746 hasConceptScore W2064695746C172680121 @default.
• W2064695746 hasConceptScore W2064695746C179335377 @default.
• W2064695746 hasConceptScore W2064695746C196843134 @default.
• W2064695746 hasConceptScore W2064695746C197934379 @default.
• W2064695746 hasConceptScore W2064695746C2779234561 @default.
• W2064695746 hasConceptScore W2064695746C2780320433 @default.
• W2064695746 hasConceptScore W2064695746C29730261 @default.
• W2064695746 hasConceptScore W2064695746C42407357 @default.
• W2064695746 hasConceptScore W2064695746C46973012 @default.
• W2064695746 hasConceptScore W2064695746C54355233 @default.
• W2064695746 hasConceptScore W2064695746C65290608 @default.
• W2064695746 hasConceptScore W2064695746C71924100 @default.
• W2064695746 hasConceptScore W2064695746C86803240 @default.
• W2064695746 hasConceptScore W2064695746C95444343 @default.
• W2064695746 hasIssue "1" @default.
• W2064695746 hasLocation W20646957461 @default.
• W2064695746 hasLocation W20646957462 @default.
• W2064695746 hasOpenAccess W2064695746 @default.
• W2064695746 hasPrimaryLocation W20646957461 @default.
• W2064695746 hasRelatedWork W1990273725 @default.
• W2064695746 hasRelatedWork W2037681128 @default.
• W2064695746 hasRelatedWork W2038918881 @default.
• W2064695746 hasRelatedWork W2040594938 @default.

• next