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- W2064697775 abstract "Water arrives in the mammalian gestation from the maternal circulation across the placenta. It then circulates between the fetal water compartments, including the fetal body compartments, the placenta and the amniotic fluid. Amniotic fluid is created by the flow of fluid from the fetal lung and bladder. A major pathway for amniotic fluid resorption is fetal swallowing; however, in many cases the amounts of fluid produced and absorbed do not balance. A second resorption pathway, the intramembranous pathway (across the amnion to the fetal circulation), has been proposed to explain the maintenance of normal amniotic fluid volume. Amniotic fluid volume is thus a function both of the amount of water transferred to the gestation across the placental membrane, and the flux of water across the amnion. Water flux across biologic membranes may be driven by osmotic or hydrostatic forces; existing data suggest that intramembranous flow in humans is driven by the osmotic difference between the amniotic fluid and the fetal serum. The driving force for placental flow is more controversial, and both forces may be in effect. The mechanism(s) responsible for regulating water flow to and from the amniotic fluid is unknown. In other parts of the body, notably the kidney, water flux is regulated by the expression of aquaporin water channels on the cell membrane. We hypothesize that aquaporins have a role in regulating water flux across both the amnion and the placenta, and present evidence in support of this theory. Current knowledge of gestational water flow is sufficient to allow prediction of fetal outcome when water flow is abnormal, as in twin-twin transfusion syndrome. Further insight into these mechanisms may allow novel treatments for amniotic fluid volume abnormalities with resultant improvement in clinical outcome." @default.
- W2064697775 created "2016-06-24" @default.
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- W2064697775 creator A5018533954 @default.
- W2064697775 creator A5043837012 @default.
- W2064697775 creator A5075730499 @default.
- W2064697775 date "2007-08-01" @default.
- W2064697775 modified "2023-09-30" @default.
- W2064697775 title "Regulation of Amniotic Fluid Volume" @default.
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- W2064697775 doi "https://doi.org/10.1016/j.placenta.2006.12.004" @default.
- W2064697775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17303237" @default.
- W2064697775 hasPublicationYear "2007" @default.
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