FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064712057> ?p ?o ?g. }

• W2064712057 endingPage "424" @default.
• W2064712057 startingPage "414" @default.
• W2064712057 abstract "Mechanical loading is an important regulatory factor in alveolar bone homeostasis, and plays an essential role in maintaining the structure and mass of the alveolar processes throughout lifetime. A better understanding of the cellular and molecular responses of periodontal cells is a prerequisite for further improvements of therapeutic approaches in orthodontics, periodontal and alveolar bone repair and regeneration, implantology, and post-surgical wound healing. The purpose of this review is to provide an insight into some cell culture and animal models used for studying the effects of mechanical loading on periodontal cells, and into the recent developments and utilization of new in vivo animal models. There has been an increased awareness about the need for improvement and development of in vivo models to supplement the widely used cell culture models, and for biological validation of in vitro results, especially in the light of evidence that developmental models may not always reflect bone homeostasis in an adult organism. Due to the limitations of in vivo models, previous studies on mechanical regulation of alveolar bone osteoblasts and cementoblasts mostly focused on proliferative responses, rather than on the stimulation of cell differentiation. To address this problem, we have recently characterized and implemented a mouse osteoinductive tooth movement model for studying mechanically induced regulation of osteoblast- and cementoblast-associated genes. In this model, a defined and reproducible mechanical osteogenic loading is applied during a time course of up to two weeks. Regulation of gene expression in either wild-type or transgenic animals is assessed by a relative quantitative measurement of the level of target mRNAs directly within the subpopulations of periodontal cells. To date, results demonstrate a defined temporal pattern of cell-specific gene regulation in periodontal osteoblasts mechanically stimulated to differentiate and deposit bone matrix. The responses of osteoblast-associated genes to mechanical loading were 10- to 20-fold greater than the increase in the numbers of these cells, indicating that the induction of differentiation and an increase of cell function are the primary responses to osteogenic loading. The progression of the osteoblast phenotype in the intact mouse periodontium was several-fold faster compared with that in cultured cells, suggesting that the mechanical signal may be targeting osteoblast precursors in the state of readiness to respond to an environmental challenge, without the initial proliferative response. An early response of alkaline phosphatase and bone sialoprotein genes was detected after 24 hrs of treatment, followed by a concomitant stimulation of osteocalcin and collagen I between 24 and 48 hrs, and deposition of osteoid after 72 hrs. Although cementoblasts constitutively express biochemical markers similar to those of osteoblasts, distinct responses of osteocalcin, collagen I, and bone sialoprotein genes to mechanical loading were observed in the two cell phenotypes. This finding indicates that differential genetic responses to mechanical loading provide functional markers for distinction of the cementoblast and osteoblast phenotypes." @default.
• W2064712057 created "2016-06-24" @default.
• W2064712057 creator A5020302454 @default.
• W2064712057 creator A5037458653 @default.
• W2064712057 date "2001-09-01" @default.
• W2064712057 modified "2023-09-24" @default.
• W2064712057 title "Effect of Mechanical Loading On Periodontal Cells" @default.
• W2064712057 cites W1540680229 @default.
• W2064712057 cites W1668585948 @default.
• W2064712057 cites W1841160455 @default.
• W2064712057 cites W1898658351 @default.
• W2064712057 cites W1902328162 @default.
• W2064712057 cites W1910689757 @default.
• W2064712057 cites W1964440437 @default.
• W2064712057 cites W1965961318 @default.
• W2064712057 cites W1967882105 @default.
• W2064712057 cites W1968687955 @default.
• W2064712057 cites W1969846958 @default.
• W2064712057 cites W1973174217 @default.
• W2064712057 cites W1976030527 @default.
• W2064712057 cites W1982267750 @default.
• W2064712057 cites W1991760159 @default.
• W2064712057 cites W1992313364 @default.
• W2064712057 cites W1992662075 @default.
• W2064712057 cites W1992663794 @default.
• W2064712057 cites W1993537084 @default.
• W2064712057 cites W1993985103 @default.
• W2064712057 cites W1997355841 @default.
• W2064712057 cites W2006297354 @default.
• W2064712057 cites W2011281192 @default.
• W2064712057 cites W2013784413 @default.
• W2064712057 cites W2014209332 @default.
• W2064712057 cites W2014429372 @default.
• W2064712057 cites W2015877034 @default.
• W2064712057 cites W2016136435 @default.
• W2064712057 cites W2016537897 @default.
• W2064712057 cites W2017159555 @default.
• W2064712057 cites W2021210245 @default.
• W2064712057 cites W2024434767 @default.
• W2064712057 cites W2025137697 @default.
• W2064712057 cites W2027790303 @default.
• W2064712057 cites W2028179193 @default.
• W2064712057 cites W2028281832 @default.
• W2064712057 cites W2035716485 @default.
• W2064712057 cites W2036867570 @default.
• W2064712057 cites W2038896879 @default.
• W2064712057 cites W2040337853 @default.
• W2064712057 cites W2042444320 @default.
• W2064712057 cites W2044971600 @default.
• W2064712057 cites W2046643585 @default.
• W2064712057 cites W2052467880 @default.
• W2064712057 cites W2054600929 @default.
• W2064712057 cites W2058707027 @default.
• W2064712057 cites W2062524697 @default.
• W2064712057 cites W2062675351 @default.
• W2064712057 cites W2064249214 @default.
• W2064712057 cites W2064712057 @default.
• W2064712057 cites W2064811241 @default.
• W2064712057 cites W2066601884 @default.
• W2064712057 cites W2066789120 @default.
• W2064712057 cites W2067986741 @default.
• W2064712057 cites W2070027660 @default.
• W2064712057 cites W2070907725 @default.
• W2064712057 cites W2072152413 @default.
• W2064712057 cites W2075674947 @default.
• W2064712057 cites W2079971241 @default.
• W2064712057 cites W2082036709 @default.
• W2064712057 cites W2083691798 @default.
• W2064712057 cites W2083878023 @default.
• W2064712057 cites W2088959492 @default.
• W2064712057 cites W2089044015 @default.
• W2064712057 cites W2104533895 @default.
• W2064712057 cites W2109441210 @default.
• W2064712057 cites W2112922155 @default.
• W2064712057 cites W2113565126 @default.
• W2064712057 cites W2113916108 @default.
• W2064712057 cites W2113969342 @default.
• W2064712057 cites W2114528551 @default.
• W2064712057 cites W2121084433 @default.
• W2064712057 cites W2121200990 @default.
• W2064712057 cites W2128118061 @default.
• W2064712057 cites W2132309525 @default.
• W2064712057 cites W2135923530 @default.
• W2064712057 cites W2150989762 @default.
• W2064712057 cites W2160743639 @default.
• W2064712057 cites W2163688233 @default.
• W2064712057 cites W2167029813 @default.
• W2064712057 cites W2406414528 @default.
• W2064712057 cites W2616312289 @default.
• W2064712057 cites W4210962462 @default.
• W2064712057 cites W4231346809 @default.
• W2064712057 doi "https://doi.org/10.1177/10454411010120050401" @default.
• W2064712057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12002823" @default.
• W2064712057 hasPublicationYear "2001" @default.
• W2064712057 type Work @default.
• W2064712057 sameAs 2064712057 @default.
• W2064712057 citedByCount "81" @default.
• W2064712057 countsByYear W20647120572012 @default.

• next