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• W2064720111 abstract "NVA237 is a once-daily inhaled long-acting muscarinic antagonist in development for the treatment of COPD.This randomized, double-blind, placebo-controlled, four-period, incomplete block crossover study, with open-label active comparator (tiotropium), assessed the efficacy and safety of NVA237. Patients (≥40 years; smoking history ≥10 pack-years) with stable moderate-to-severe COPD (post-bronchodilator FEV1 ≥ 30% and <80% predicted, FEV1/FVC < 0.7) received NVA237 12.5, 25, 50 or 100 μg, placebo, or tiotropium 18 μg once-daily for 7 days. The primary endpoint was mean trough (23–24 h post-dose) FEV1 on Day 7. Secondary endpoints included mean trough FEV1 on Day 1, and FEV1 and FVC at individual time points post-dose on Days 1 and 7. 83 patients (mean age 64.4 years; male 83.1%; mean COPD duration 6.7 years; mean post-bronchodilator FEV1 1.5 L/52.7% predicted) were randomized; 78 completed. Mean trough FEV1 on Day 7 and Day 1 was significantly higher with all active treatments versus placebo (p < 0.05). NVA237 50 μg, 100 μg and tiotropium showed clinically relevant improvements versus placebo on Day 7 (differences of 131, 142 and 127 mL, respectively; p < 0.0001) and 1 (differences of 121, 135 and 112 mL, respectively; p < 0.0001). On Day 1, but not Day 7, FEV1 was significantly higher (p < 0.05) with NVA237 50 and 100 μg versus tiotropium from 5 min up to 2 and 4 h post-dose, respectively. All doses of NVA237 and tiotropium were well tolerated.NVA237 once-daily was effective and well tolerated versus placebo, and demonstrated rapid and sustained 24-h bronchodilation. (ClinicalTrials.gov Identifier: NCT00501852)." @default.
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• W2064720111 date "2010-10-01" @default.
• W2064720111 modified "2023-09-24" @default.
• W2064720111 title "Sustained 24-h efficacy of NVA237, a once-daily long-acting muscarinic antagonist, in COPD patients" @default.
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• W2064720111 doi "https://doi.org/10.1016/j.rmed.2010.04.006" @default.
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