FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064724020> ?p ?o ?g. }

• W2064724020 endingPage "362" @default.
• W2064724020 startingPage "352" @default.
• W2064724020 abstract "The developmental sequence of the embryonic joint has been well studied morphologically. There are, however, no definitive studies of cell function during joint development. In order to begin to understand the differentiation events that contribute to joint formation, we examined the expression of collagen mRNAs encoding types I, IIA, IIB, and XI. In situ hybridization was performed on chicken embryo hind limb buds and digits from day 7 to day 18 (Hamburger and Hamilton stages 31–44). In the day 7 (stage 31) limb bud, there was a condensation of mesenchyme forming the primitive tarsal and metatarsal bones that showed abundant expression of type IIA procollagen message, but no type IIB or type α1(XI) message. By day 8 (stage 33), co-expression of types IIA, and type XI procollagen mRNAs was observed in the condensations, with expression of IIB restricted to early chondrocytes with metachromatically staining matrix. At this stage, DNA fragmentation characteristic of apoptosis was observed in cells near the midline of the interzone region between the developing anlagen, and in areas between and around the individual digits of the paddle. The presumptive apoptotic cells were more numerous at day 9 (stage 35), and were not found in the developing joint at subsequent time points, including the initiation of spatial cavitation of the joint. From days 11–18, type IIA procollagen mRNA was expressed in flattened cells at the surface of the anlagen, and in the perichondrium and in the developing joint capsule; type IIB mRNA message was found only in chondrocytes. Type XI mRNA was expressed by all type II-expressing cells. Alpha 1(I) mRNA was expressed early by cells of th8e interzone and capsule, but as cavitation progressed, the type I expressing cells of the interzone merged with the superficial layer of the articular surface. Thus, at the time of joint cavitation, there was a distinct pattern of expression of procollagen messages at the articular surface, with type I being outermost, followed by morphologically similar cells expressing type IIA, then chondrocytes expressing type IIB. The progenitor cells expressing type IIA message define a new population of cells. These cell populations contribute to the molecular heterogeneity of the articular cartilage, and these same populations likely exist in the developing joints of other species. The transient transcription of type II and type XI collagen genes, characteristic of chondrocytes, by cells in the joint capsule demonstrates that these cells may have chondrogenic potential. ©1995 Wiley-Liss, Inc." @default.
• W2064724020 created "2016-06-24" @default.
• W2064724020 creator A5000442483 @default.
• W2064724020 creator A5005225168 @default.
• W2064724020 creator A5082172901 @default.
• W2064724020 date "1995-07-01" @default.
• W2064724020 modified "2023-10-17" @default.
• W2064724020 title "Collagen gene expression during development of avian synovial joints: Transient expression of types II and XI collagen genes in the joint capsule" @default.
• W2064724020 cites W1525977186 @default.
• W2064724020 cites W1530292186 @default.
• W2064724020 cites W1544802519 @default.
• W2064724020 cites W1551318802 @default.
• W2064724020 cites W1606921260 @default.
• W2064724020 cites W1879756149 @default.
• W2064724020 cites W1964072966 @default.
• W2064724020 cites W1966460840 @default.
• W2064724020 cites W1969497587 @default.
• W2064724020 cites W1971454187 @default.
• W2064724020 cites W1996327628 @default.
• W2064724020 cites W2022813157 @default.
• W2064724020 cites W2023434589 @default.
• W2064724020 cites W2045631728 @default.
• W2064724020 cites W2046312093 @default.
• W2064724020 cites W2051349620 @default.
• W2064724020 cites W2075488484 @default.
• W2064724020 cites W2078382718 @default.
• W2064724020 cites W2081418368 @default.
• W2064724020 cites W2082481235 @default.
• W2064724020 cites W2104887669 @default.
• W2064724020 cites W2130013083 @default.
• W2064724020 cites W2138302361 @default.
• W2064724020 cites W2163890147 @default.
• W2064724020 cites W69873029 @default.
• W2064724020 cites W77735167 @default.
• W2064724020 doi "https://doi.org/10.1002/aja.1002030307" @default.
• W2064724020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8589432" @default.
• W2064724020 hasPublicationYear "1995" @default.
• W2064724020 type Work @default.
• W2064724020 sameAs 2064724020 @default.
• W2064724020 citedByCount "92" @default.
• W2064724020 countsByYear W20647240202012 @default.
• W2064724020 countsByYear W20647240202013 @default.
• W2064724020 countsByYear W20647240202014 @default.
• W2064724020 countsByYear W20647240202015 @default.
• W2064724020 countsByYear W20647240202016 @default.
• W2064724020 countsByYear W20647240202017 @default.
• W2064724020 countsByYear W20647240202018 @default.
• W2064724020 countsByYear W20647240202019 @default.
• W2064724020 countsByYear W20647240202020 @default.
• W2064724020 countsByYear W20647240202021 @default.
• W2064724020 crossrefType "journal-article" @default.
• W2064724020 hasAuthorship W2064724020A5000442483 @default.
• W2064724020 hasAuthorship W2064724020A5005225168 @default.
• W2064724020 hasAuthorship W2064724020A5082172901 @default.
• W2064724020 hasConcept C104317684 @default.
• W2064724020 hasConcept C105702510 @default.
• W2064724020 hasConcept C150194340 @default.
• W2064724020 hasConcept C153911025 @default.
• W2064724020 hasConcept C196843134 @default.
• W2064724020 hasConcept C25515809 @default.
• W2064724020 hasConcept C25770073 @default.
• W2064724020 hasConcept C2776340970 @default.
• W2064724020 hasConcept C2778751288 @default.
• W2064724020 hasConcept C2780550940 @default.
• W2064724020 hasConcept C2781013607 @default.
• W2064724020 hasConcept C54355233 @default.
• W2064724020 hasConcept C64348721 @default.
• W2064724020 hasConcept C81439078 @default.
• W2064724020 hasConcept C86803240 @default.
• W2064724020 hasConcept C95444343 @default.
• W2064724020 hasConceptScore W2064724020C104317684 @default.
• W2064724020 hasConceptScore W2064724020C105702510 @default.
• W2064724020 hasConceptScore W2064724020C150194340 @default.
• W2064724020 hasConceptScore W2064724020C153911025 @default.
• W2064724020 hasConceptScore W2064724020C196843134 @default.
• W2064724020 hasConceptScore W2064724020C25515809 @default.
• W2064724020 hasConceptScore W2064724020C25770073 @default.
• W2064724020 hasConceptScore W2064724020C2776340970 @default.
• W2064724020 hasConceptScore W2064724020C2778751288 @default.
• W2064724020 hasConceptScore W2064724020C2780550940 @default.
• W2064724020 hasConceptScore W2064724020C2781013607 @default.
• W2064724020 hasConceptScore W2064724020C54355233 @default.
• W2064724020 hasConceptScore W2064724020C64348721 @default.
• W2064724020 hasConceptScore W2064724020C81439078 @default.
• W2064724020 hasConceptScore W2064724020C86803240 @default.
• W2064724020 hasConceptScore W2064724020C95444343 @default.
• W2064724020 hasIssue "3" @default.
• W2064724020 hasLocation W20647240201 @default.
• W2064724020 hasLocation W20647240202 @default.
• W2064724020 hasOpenAccess W2064724020 @default.
• W2064724020 hasPrimaryLocation W20647240201 @default.
• W2064724020 hasRelatedWork W1972476309 @default.
• W2064724020 hasRelatedWork W1982743231 @default.
• W2064724020 hasRelatedWork W2020463293 @default.
• W2064724020 hasRelatedWork W2023156173 @default.
• W2064724020 hasRelatedWork W2053002098 @default.
• W2064724020 hasRelatedWork W2078382718 @default.
• W2064724020 hasRelatedWork W2081156898 @default.

• next