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• W2064726579 abstract "Many genes are regulated at the level of a Pol II that is recruited to a nucleosome-free region upstream of the +1 nucleosome. How the Mediator coactivator complex, which functions at multiple steps, affects transcription through the promoter proximal region, including this nucleosome, remains largely unaddressed. We have established a fully defined in vitro assay system to delineate mechanisms for Pol II transit across the +1 nucleosome. Our results reveal cooperative functions of multiple cofactors, particularly of Mediator and elongation factor SII, in transcribing into this nucleosome. This is achieved, in part, through an unusual activity of SII that alters the intrinsic catalytic properties of promoter-proximal Pol II and, in concert with the Mediator, leads to enhancement in transcription of nucleosomal DNA. Our data provide additional mechanistic bases for Mediator function after recruitment of Pol II and, potentially, for regulation of genes controlled via nucleosome-mediated promoter-proximal pausing." @default.
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• W2064726579 date "2012-12-01" @default.
• W2064726579 modified "2023-10-13" @default.
• W2064726579 title "Mediator-Regulated Transcription through the +1 Nucleosome" @default.
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• W2064726579 doi "https://doi.org/10.1016/j.molcel.2012.10.009" @default.
• W2064726579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3534924" @default.
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