FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064729564> ?p ?o ?g. }

• W2064729564 endingPage "52" @default.
• W2064729564 startingPage "40" @default.
• W2064729564 abstract "Increasing knowledge of the role of nitric oxide (NO) in physiology and disease has stimulated efforts to target the NO pathway pharmacologically. These therapeutic strategies include NO donors that directly or indirectly release NO and agents that increase NO bioactivity. Traditional organic nitrates such as nitroglycerin, which indirectly release NO, were believed to have limited long-term efficacy and tolerability, chiefly because of nitrate tolerance. Recent studies, however, suggest more effective ways of using these agents and new applications for them. Nicorandil, a hybrid organic nitrate that also activates potassium channels, has demonstrated significant benefits in acute coronary syndromes. Other nitrates are being investigated for use in neurodegenerative diseases. Direct NO donors include NO gas, which is useful in respiratory disorders, and the more recent classes of diazeniumdiolates, sydnonimines, and S-nitrosothiols. Preliminary data suggest that these agents may be effective as antiatherosclerotic agents as well as in other disease states. In addition, hybrid agents that consist of an NO donor coupled with a parent anti-inflammatory drug, including nonsteroidal anti-inflammatory drugs, have demonstrated enhanced efficacy and tolerability compared with the anti-inflammatory parent drug alone in diverse experimental models. Established drugs that enhance NO bioactivity include antihypertensive agents, particularly angiotensin-converting enzyme inhibitors, calcium channel blockers, and newer vasodilating beta-blockers. In addition, 3-methylglutaryl coenzyme A reductase inhibitors (statins) promote NO bioactivity, both through and independent of lipid lowering. The NO-promoting actions of these established drugs provide some insight into their known benefits and suggest possible therapeutic potential." @default.
• W2064729564 created "2016-06-24" @default.
• W2064729564 creator A5003822075 @default.
• W2064729564 creator A5078947886 @default.
• W2064729564 date "2006-12-01" @default.
• W2064729564 modified "2023-10-04" @default.
• W2064729564 title "Targeting Nitric Oxide With Drug Therapy" @default.
• W2064729564 cites W1130937769 @default.
• W2064729564 cites W1571937066 @default.
• W2064729564 cites W1860278769 @default.
• W2064729564 cites W1896208327 @default.
• W2064729564 cites W1963635094 @default.
• W2064729564 cites W1965619184 @default.
• W2064729564 cites W1967201354 @default.
• W2064729564 cites W1969488665 @default.
• W2064729564 cites W1970696414 @default.
• W2064729564 cites W1970729969 @default.
• W2064729564 cites W1971377175 @default.
• W2064729564 cites W1974081986 @default.
• W2064729564 cites W1977429372 @default.
• W2064729564 cites W1979574798 @default.
• W2064729564 cites W1982141048 @default.
• W2064729564 cites W1982600332 @default.
• W2064729564 cites W1983768623 @default.
• W2064729564 cites W1984860118 @default.
• W2064729564 cites W1985198002 @default.
• W2064729564 cites W1985832424 @default.
• W2064729564 cites W1986017743 @default.
• W2064729564 cites W1989786292 @default.
• W2064729564 cites W1991503132 @default.
• W2064729564 cites W1992547254 @default.
• W2064729564 cites W1993378083 @default.
• W2064729564 cites W1994506978 @default.
• W2064729564 cites W1994783231 @default.
• W2064729564 cites W1995435926 @default.
• W2064729564 cites W1996329028 @default.
• W2064729564 cites W1996940198 @default.
• W2064729564 cites W1997256771 @default.
• W2064729564 cites W2002654604 @default.
• W2064729564 cites W2004641607 @default.
• W2064729564 cites W2005608816 @default.
• W2064729564 cites W2006657091 @default.
• W2064729564 cites W2007595474 @default.
• W2064729564 cites W2008767716 @default.
• W2064729564 cites W2009018570 @default.
• W2064729564 cites W2010399852 @default.
• W2064729564 cites W2010921303 @default.
• W2064729564 cites W2016862942 @default.
• W2064729564 cites W2019044547 @default.
• W2064729564 cites W2022325044 @default.
• W2064729564 cites W2022390344 @default.
• W2064729564 cites W2023617092 @default.
• W2064729564 cites W2024150029 @default.
• W2064729564 cites W2027872608 @default.
• W2064729564 cites W2030300135 @default.
• W2064729564 cites W2032687994 @default.
• W2064729564 cites W2036886263 @default.
• W2064729564 cites W2037657203 @default.
• W2064729564 cites W2038804822 @default.
• W2064729564 cites W2041037406 @default.
• W2064729564 cites W2041569877 @default.
• W2064729564 cites W2042434957 @default.
• W2064729564 cites W2043595406 @default.
• W2064729564 cites W2044422396 @default.
• W2064729564 cites W2046478130 @default.
• W2064729564 cites W2047631855 @default.
• W2064729564 cites W2049316656 @default.
• W2064729564 cites W2051048068 @default.
• W2064729564 cites W2051847946 @default.
• W2064729564 cites W2054278465 @default.
• W2064729564 cites W2055147450 @default.
• W2064729564 cites W2064569428 @default.
• W2064729564 cites W2067889393 @default.
• W2064729564 cites W2068423934 @default.
• W2064729564 cites W2070310436 @default.
• W2064729564 cites W2070763907 @default.
• W2064729564 cites W2071468916 @default.
• W2064729564 cites W2071823872 @default.
• W2064729564 cites W2072073145 @default.
• W2064729564 cites W2072348717 @default.
• W2064729564 cites W2072597464 @default.
• W2064729564 cites W2072868634 @default.
• W2064729564 cites W2073505488 @default.
• W2064729564 cites W2077835439 @default.
• W2064729564 cites W2081219055 @default.
• W2064729564 cites W2082291507 @default.
• W2064729564 cites W2084304010 @default.
• W2064729564 cites W2084662085 @default.
• W2064729564 cites W2087780444 @default.
• W2064729564 cites W2088145115 @default.
• W2064729564 cites W2089258822 @default.
• W2064729564 cites W2090597550 @default.
• W2064729564 cites W2091301735 @default.
• W2064729564 cites W2091530696 @default.
• W2064729564 cites W2092742533 @default.
• W2064729564 cites W2092976211 @default.
• W2064729564 cites W2093724437 @default.
• W2064729564 cites W2094420414 @default.

• next