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- W2064736089 abstract "Although observational studies are a relatively inexpensive and rapid alternative to randomized controlled trials, critics argue that observational studies lack internal validity. For example, indication bias may limit the reliability of outcomes data from observational studies on the cost or safety of alternative pharmacotherapy. The workshop will focus on the novel use of data on prior medications to document the extent of confounding by indication. Current research on use of anti-hypertensive and antianginal medications in a Medicaid population will be used to illustrate recommended methods for designing and conducting observational studies. Topics covered will include assessing and classifying the duration and classes of prior medication history, sequencing of risk factors and adjusting for severity of disease. The on-going controversy over the safety of calcium channel blockers will be examined in light of evidence on confounding by indication. The presenters' own research will be used to explore the evidentiary basis for current claims and counter claims as well as the weakness of data on the key intervening variable-exposure to the study drugs. The workshop material is aimed at researchers with hands-on experience using administrative databases as well as industry sponsors of outcome studies. The workshop addresses the themes of enhancing the usefulness of outcomes research for providers and insurers by strengthening current methods for identifying and eliminating systematic biases." @default.
- W2064736089 created "2016-06-24" @default.
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- W2064736089 date "1998-05-01" @default.
- W2064736089 modified "2023-09-26" @default.
- W2064736089 title "DA1 Using Medication History to Measure Indication Bias" @default.
- W2064736089 doi "https://doi.org/10.1046/j.1524-4733.1998.1100871.x" @default.
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