FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064739148> ?p ?o ?g. }

• W2064739148 endingPage "2900" @default.
• W2064739148 startingPage "2892" @default.
• W2064739148 abstract "The significance of thrombocytopenia in patients experiencing an acute coronary syndrome (ACS) has not been examined systematically. We evaluated this condition in a large non-ST-elevation ACS clinical trial, with particular interest paid to its correlation with clinical outcomes.Patients presenting without persistent ST elevation during an ACS were randomized to receive a double-blind infusion of the platelet glycoprotein (GP) IIb/IIIa inhibitor eptifibatide or placebo in addition to other standard therapies including heparin and aspirin. The primary end point was death/nonfatal myocardial infarction (MI) at 30 days, whereas bleeding and stroke were the main safety outcomes. Thrombocytopenia (nadir platelet count <100x10(9)/L or <50% of baseline) occurred in 7.0% of enrolled patients. The time to onset was a median of 4 days in both treatment arms. Patients with thrombocytopenia were older, weighed less, were more likely nonwhite, and had more cardiac risk factors. These patients experienced significantly more bleeding events: they were more than twice as likely to experience moderate/severe bleeding after adjustment for confounders. Univariably, ischemic events (stroke, MI, and death) occurred significantly (P<0.001) more frequently in patients with thrombocytopenia; multivariable regression modeling preserved this association with death/nonfatal MI at 30 days. Neither the use of heparin or eptifibatide was found to independently increase thrombocytopenic risk.Although causality between thrombocytopenia and adverse clinical events could not be established definitively, thrombocytopenia was highly correlated with both bleeding and ischemic events, and the presence of this condition identified a more-at-risk patient population." @default.
• W2064739148 created "2016-06-24" @default.
• W2064739148 creator A5001994412 @default.
• W2064739148 creator A5013408607 @default.
• W2064739148 creator A5015018500 @default.
• W2064739148 creator A5015610233 @default.
• W2064739148 creator A5036750574 @default.
• W2064739148 creator A5038032397 @default.
• W2064739148 creator A5039754301 @default.
• W2064739148 creator A5047661952 @default.
• W2064739148 creator A5055052720 @default.
• W2064739148 creator A5057323746 @default.
• W2064739148 creator A5060370891 @default.
• W2064739148 creator A5060829829 @default.
• W2064739148 creator A5079156387 @default.
• W2064739148 creator A5084515381 @default.
• W2064739148 creator A5084631368 @default.
• W2064739148 creator A5087089751 @default.
• W2064739148 date "1999-06-08" @default.
• W2064739148 modified "2023-10-10" @default.
• W2064739148 title "Clinical Significance of Thrombocytopenia During a Non–ST-Elevation Acute Coronary Syndrome" @default.
• W2064739148 cites W1596397105 @default.
• W2064739148 cites W1991427041 @default.
• W2064739148 cites W2014572752 @default.
• W2064739148 cites W2025135083 @default.
• W2064739148 cites W2033187214 @default.
• W2064739148 cites W2085869089 @default.
• W2064739148 cites W2108361166 @default.
• W2064739148 cites W2118895431 @default.
• W2064739148 cites W2269771058 @default.
• W2064739148 cites W2333983635 @default.
• W2064739148 cites W4254984483 @default.
• W2064739148 cites W4256202725 @default.
• W2064739148 doi "https://doi.org/10.1161/01.cir.99.22.2892" @default.
• W2064739148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10359733" @default.
• W2064739148 hasPublicationYear "1999" @default.
• W2064739148 type Work @default.
• W2064739148 sameAs 2064739148 @default.
• W2064739148 citedByCount "138" @default.
• W2064739148 countsByYear W20647391482012 @default.
• W2064739148 countsByYear W20647391482013 @default.
• W2064739148 countsByYear W20647391482014 @default.
• W2064739148 countsByYear W20647391482015 @default.
• W2064739148 countsByYear W20647391482016 @default.
• W2064739148 countsByYear W20647391482017 @default.
• W2064739148 countsByYear W20647391482018 @default.
• W2064739148 countsByYear W20647391482019 @default.
• W2064739148 countsByYear W20647391482020 @default.
• W2064739148 countsByYear W20647391482021 @default.
• W2064739148 countsByYear W20647391482022 @default.
• W2064739148 crossrefType "journal-article" @default.
• W2064739148 hasAuthorship W2064739148A5001994412 @default.
• W2064739148 hasAuthorship W2064739148A5013408607 @default.
• W2064739148 hasAuthorship W2064739148A5015018500 @default.
• W2064739148 hasAuthorship W2064739148A5015610233 @default.
• W2064739148 hasAuthorship W2064739148A5036750574 @default.
• W2064739148 hasAuthorship W2064739148A5038032397 @default.
• W2064739148 hasAuthorship W2064739148A5039754301 @default.
• W2064739148 hasAuthorship W2064739148A5047661952 @default.
• W2064739148 hasAuthorship W2064739148A5055052720 @default.
• W2064739148 hasAuthorship W2064739148A5057323746 @default.
• W2064739148 hasAuthorship W2064739148A5060370891 @default.
• W2064739148 hasAuthorship W2064739148A5060829829 @default.
• W2064739148 hasAuthorship W2064739148A5079156387 @default.
• W2064739148 hasAuthorship W2064739148A5084515381 @default.
• W2064739148 hasAuthorship W2064739148A5084631368 @default.
• W2064739148 hasAuthorship W2064739148A5087089751 @default.
• W2064739148 hasBestOaLocation W20647391481 @default.
• W2064739148 hasConcept C126322002 @default.
• W2064739148 hasConcept C127413603 @default.
• W2064739148 hasConcept C142724271 @default.
• W2064739148 hasConcept C164705383 @default.
• W2064739148 hasConcept C204787440 @default.
• W2064739148 hasConcept C27081682 @default.
• W2064739148 hasConcept C2776335557 @default.
• W2064739148 hasConcept C2777628954 @default.
• W2064739148 hasConcept C2777698277 @default.
• W2064739148 hasConcept C2777849778 @default.
• W2064739148 hasConcept C2780400711 @default.
• W2064739148 hasConcept C2780645631 @default.
• W2064739148 hasConcept C2781056559 @default.
• W2064739148 hasConcept C2908647359 @default.
• W2064739148 hasConcept C500558357 @default.
• W2064739148 hasConcept C71924100 @default.
• W2064739148 hasConcept C78519656 @default.
• W2064739148 hasConcept C99454951 @default.
• W2064739148 hasConceptScore W2064739148C126322002 @default.
• W2064739148 hasConceptScore W2064739148C127413603 @default.
• W2064739148 hasConceptScore W2064739148C142724271 @default.
• W2064739148 hasConceptScore W2064739148C164705383 @default.
• W2064739148 hasConceptScore W2064739148C204787440 @default.
• W2064739148 hasConceptScore W2064739148C27081682 @default.
• W2064739148 hasConceptScore W2064739148C2776335557 @default.
• W2064739148 hasConceptScore W2064739148C2777628954 @default.
• W2064739148 hasConceptScore W2064739148C2777698277 @default.
• W2064739148 hasConceptScore W2064739148C2777849778 @default.
• W2064739148 hasConceptScore W2064739148C2780400711 @default.
• W2064739148 hasConceptScore W2064739148C2780645631 @default.

• next