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- W2064742751 abstract "Purpose of review Pulmonary arterial hypertension (PAH) is an important cause of morbidity and mortality in children. Approved medications for the treatment of adult PAH have been used to treat children, but evidence-based treatment algorithms for children are lacking. Recent findings Pediatric PAH registries have begun to define the incidence and prevalence of idiopathic PAH and PAH associated with congenital heart disease. A pediatric-specific classification of pulmonary hypertensive vascular disease has been proposed. Furthermore, the first randomized placebo-controlled trial of type-5 phosphodiesterase therapy in treatment-naïve children with PAH has been completed and reported. This trial highlights the importance of the difficulties of performing clinical trials in children with targeted PAH therapy as well as the importance of long-term follow-up of adverse events. Summary Classification, clinical trials, and therapy for children with PAH must take into account the unique aspects of PAH in children." @default.
- W2064742751 created "2016-06-24" @default.
- W2064742751 creator A5023923057 @default.
- W2064742751 date "2012-03-01" @default.
- W2064742751 modified "2023-09-25" @default.
- W2064742751 title "Advances in pediatric pulmonary arterial hypertension" @default.
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- W2064742751 doi "https://doi.org/10.1097/hco.0b013e32835018cd" @default.
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