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- W2064746468 abstract "Anti-aquaporin 4 (AQP4) antibodies (Abs) are essential in neuromyelitis optica spectrum disorders (NMOSD), but the relationship between CNS demyelinating disorders (CNSDD) and other neural Abs remains unclear. Here we screened anti-neural Abs in the sera of 70 Japanese CNSDD patients. While two had only demyelinating events among three anti-N-methyl-d-aspartate receptor (NMDAR) Ab-positive subjects, the other subject who also had anti-AQP4 Abs experienced episodes of anti-NMDAR encephalitis and of NMOSD. Major lesions in the three anti-contactin-associated protein 2 Ab-positive subjects were infratentorial, including one co-carrying anti-AQP4 Abs. Thus, autoantibodies can be clinically silent, but multiple autoantibodies may participate in the pathogenesis." @default.
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- W2064746468 date "2014-09-01" @default.
- W2064746468 modified "2023-09-27" @default.
- W2064746468 title "Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders" @default.
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- W2064746468 doi "https://doi.org/10.1016/j.jneuroim.2014.06.020" @default.
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