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- W2064751912 abstract "Hox factors are key regulators of distinct cells, tissues, and organs along the body plan. However, little is known about how Hox factors regulate cell-specific gene expression to pattern diverse tissues. Here, we show an unexpected Hox transcriptional mechanism: the permissive regulation of EGF secretion, and thereby cell specification, by antagonizing the Senseless transcription factor in the peripheral nervous system. rhomboid expression in a subset of sensory cells stimulates EGF secretion to induce hepatocyte-like cell development. We identified a rhomboid enhancer that is active in these cells and show that an abdominal Hox complex directly competes with Senseless for enhancer binding, with the transcriptional outcome dependent upon their relative binding activities. Thus, Hox-Senseless antagonism forms a molecular switch that integrates neural and anterior-posterior positional information. As the vertebrate senseless homolog is essential for neural development as well as hematopoiesis, we propose Hox-Senseless antagonism will broadly control cell fate decisions." @default.
- W2064751912 created "2016-06-24" @default.
- W2064751912 creator A5013122328 @default.
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- W2064751912 creator A5050419480 @default.
- W2064751912 creator A5068449496 @default.
- W2064751912 creator A5086645286 @default.
- W2064751912 date "2008-08-01" @default.
- W2064751912 modified "2023-10-17" @default.
- W2064751912 title "Hox and Senseless Antagonism Functions as a Molecular Switch to Regulate EGF Secretion in the Drosophila PNS" @default.
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- W2064751912 cites W1972538107 @default.
- W2064751912 cites W1978797592 @default.
- W2064751912 cites W1979798449 @default.
- W2064751912 cites W1980366949 @default.
- W2064751912 cites W1981360723 @default.
- W2064751912 cites W1994396897 @default.
- W2064751912 cites W1998020029 @default.
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- W2064751912 cites W2009851083 @default.
- W2064751912 cites W2013935392 @default.
- W2064751912 cites W2026916779 @default.
- W2064751912 cites W2033966793 @default.
- W2064751912 cites W2036207377 @default.
- W2064751912 cites W2043655216 @default.
- W2064751912 cites W2044382442 @default.
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- W2064751912 cites W2157679927 @default.
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- W2064751912 doi "https://doi.org/10.1016/j.devcel.2008.06.001" @default.
- W2064751912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2610489" @default.
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