FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064752685> ?p ?o ?g. }

• W2064752685 endingPage "250" @default.
• W2064752685 startingPage "240" @default.
• W2064752685 abstract ": Chronic models of inflammatory bowel disease are lacking in preadult rodents. The primary goal of our study was to develop a chronic model of hapten-induced intestinal inflammation and fibrosis in young rats. Second, we aimed to determine the profiles of key Th-1, Th-2, and Th-17 proinflammatory and profibrotic cytokines, during the progression of colitis in young rats.Chronic hapten-induced colitis was induced by the administration of intracolonic 2,4,6-trinitrobenzene sulfonic acid (TNBS) in young Wistar rats (postnatal days 23, 35, 48, and 59). After 1, 3, or 4 cycles of TNBS, rats were euthanized and the colons were removed for the measurement of macroscopic, histologic, and biochemical parameters of colitis.Young rats developed moderate to severe colitis in the distal colon, without significant morbidity or mortality. Macroscopic severity, histologic pathology, and colonic weights increased progressively with repeated TNBS administration. Cobblestone-like ulceration and fibrosis was evident in the colon, particularly after 4 cycles of TNBS. There was a unique cytokine pattern associated with colitis in young rats. Interleukin (IL)-12 and tumor necrosis factor (TNF)-alpha peaked during the earlier postnatal time points (days 28 and 54) and then declined after repetitive administration of the hapten (day 67). In contrast, IL-13 and IL-17 were consistently elevated after administration of TNBS to the colon of young rats.A new model of colitis was established in young rats, which has a unique pattern of Th-1, Th-2, and Th-17 cytokine induction. This chronic TNBS model may be useful for studying the development of inflammation and fibrosis in preadult animals." @default.
• W2064752685 created "2016-06-24" @default.
• W2064752685 creator A5031791520 @default.
• W2064752685 creator A5034310331 @default.
• W2064752685 creator A5035340822 @default.
• W2064752685 creator A5067428435 @default.
• W2064752685 creator A5084391269 @default.
• W2064752685 creator A5091225355 @default.
• W2064752685 date "2010-03-01" @default.
• W2064752685 modified "2023-10-02" @default.
• W2064752685 title "A New Model of Chronic Hapten-induced Colitis in Young Rats" @default.
• W2064752685 cites W1515729929 @default.
• W2064752685 cites W1553269519 @default.
• W2064752685 cites W1970693350 @default.
• W2064752685 cites W1980018183 @default.
• W2064752685 cites W2001229417 @default.
• W2064752685 cites W2001835390 @default.
• W2064752685 cites W2008856924 @default.
• W2064752685 cites W2016537283 @default.
• W2064752685 cites W2021615571 @default.
• W2064752685 cites W2026304044 @default.
• W2064752685 cites W2034186220 @default.
• W2064752685 cites W2051591207 @default.
• W2064752685 cites W2064976423 @default.
• W2064752685 cites W2065792169 @default.
• W2064752685 cites W2070715537 @default.
• W2064752685 cites W2071523096 @default.
• W2064752685 cites W2087530820 @default.
• W2064752685 cites W2091653067 @default.
• W2064752685 cites W2122939321 @default.
• W2064752685 cites W2126874760 @default.
• W2064752685 cites W2133226723 @default.
• W2064752685 cites W2134728320 @default.
• W2064752685 cites W2140579805 @default.
• W2064752685 cites W2145381197 @default.
• W2064752685 cites W2163968913 @default.
• W2064752685 cites W2165928553 @default.
• W2064752685 cites W4254679467 @default.
• W2064752685 doi "https://doi.org/10.1097/mpg.0b013e3181cb8f4a" @default.
• W2064752685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20118800" @default.
• W2064752685 hasPublicationYear "2010" @default.
• W2064752685 type Work @default.
• W2064752685 sameAs 2064752685 @default.
• W2064752685 citedByCount "19" @default.
• W2064752685 countsByYear W20647526852012 @default.
• W2064752685 countsByYear W20647526852013 @default.
• W2064752685 countsByYear W20647526852014 @default.
• W2064752685 countsByYear W20647526852015 @default.
• W2064752685 countsByYear W20647526852016 @default.
• W2064752685 countsByYear W20647526852018 @default.
• W2064752685 countsByYear W20647526852019 @default.
• W2064752685 countsByYear W20647526852020 @default.
• W2064752685 countsByYear W20647526852021 @default.
• W2064752685 crossrefType "journal-article" @default.
• W2064752685 hasAuthorship W2064752685A5031791520 @default.
• W2064752685 hasAuthorship W2064752685A5034310331 @default.
• W2064752685 hasAuthorship W2064752685A5035340822 @default.
• W2064752685 hasAuthorship W2064752685A5067428435 @default.
• W2064752685 hasAuthorship W2064752685A5084391269 @default.
• W2064752685 hasAuthorship W2064752685A5091225355 @default.
• W2064752685 hasConcept C126322002 @default.
• W2064752685 hasConcept C164027704 @default.
• W2064752685 hasConcept C17991360 @default.
• W2064752685 hasConcept C203014093 @default.
• W2064752685 hasConcept C2775862500 @default.
• W2064752685 hasConcept C2776914184 @default.
• W2064752685 hasConcept C2778260677 @default.
• W2064752685 hasConcept C2778690821 @default.
• W2064752685 hasConcept C2779134260 @default.
• W2064752685 hasConcept C2780559512 @default.
• W2064752685 hasConcept C71924100 @default.
• W2064752685 hasConcept C90924648 @default.
• W2064752685 hasConceptScore W2064752685C126322002 @default.
• W2064752685 hasConceptScore W2064752685C164027704 @default.
• W2064752685 hasConceptScore W2064752685C17991360 @default.
• W2064752685 hasConceptScore W2064752685C203014093 @default.
• W2064752685 hasConceptScore W2064752685C2775862500 @default.
• W2064752685 hasConceptScore W2064752685C2776914184 @default.
• W2064752685 hasConceptScore W2064752685C2778260677 @default.
• W2064752685 hasConceptScore W2064752685C2778690821 @default.
• W2064752685 hasConceptScore W2064752685C2779134260 @default.
• W2064752685 hasConceptScore W2064752685C2780559512 @default.
• W2064752685 hasConceptScore W2064752685C71924100 @default.
• W2064752685 hasConceptScore W2064752685C90924648 @default.
• W2064752685 hasIssue "3" @default.
• W2064752685 hasLocation W20647526851 @default.
• W2064752685 hasLocation W20647526852 @default.
• W2064752685 hasOpenAccess W2064752685 @default.
• W2064752685 hasPrimaryLocation W20647526851 @default.
• W2064752685 hasRelatedWork W1979852216 @default.
• W2064752685 hasRelatedWork W1997810015 @default.
• W2064752685 hasRelatedWork W2023339880 @default.
• W2064752685 hasRelatedWork W2070650056 @default.
• W2064752685 hasRelatedWork W2146127186 @default.
• W2064752685 hasRelatedWork W2598386321 @default.
• W2064752685 hasRelatedWork W2743839193 @default.
• W2064752685 hasRelatedWork W2888152242 @default.
• W2064752685 hasRelatedWork W3177075541 @default.

• next