FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064754955> ?p ?o ?g. }

• W2064754955 endingPage "101" @default.
• W2064754955 startingPage "95" @default.
• W2064754955 abstract "Recent experiments from several laboratories have shown that chloroperoxidase is able to catalyze a broad spectrum of stereoselective hydroxylation, sulfoxidation and epoxidation reactions. Our laboratory has investigated the substrate specificity of chloroperoxidase for chiral epoxidation of mono- and disubstituted alkenes. Chloroperoxidase is able to efficiently utilize alkenes having chain lengths of nine or fewer carbon atoms except for monosubstituted olefins which often function as reversible suicide inhibitors of the enzyme. Excellent substrates are created by cis-1-methyl and 2-methyl substitutions on the olefinic double bond. Kinetic, enantioselectivity and epoxide yield data have been obtained on a series of brominated and unbrominated methallyl alkenes and substituted styrenes. The results indicate that methallyl alkenes and styrenes can function as good substrates. Km values for the methallyl substrates are in the millimolar range and the Vmax's reach turnovers of 200 per min. Hammett plot data are consistent with the formation of a radical as opposed to a carbocation intermediate in the rate determining step in the epoxidation of substituted styrenes. Many of the epoxide products derived from chloroperoxidase catalysis can serve as chiral synthons for drug and natural product synthesis." @default.
• W2064754955 created "2016-06-24" @default.
• W2064754955 creator A5003813749 @default.
• W2064754955 creator A5006265865 @default.
• W2064754955 creator A5062465747 @default.
• W2064754955 date "1998-09-01" @default.
• W2064754955 modified "2023-10-17" @default.
• W2064754955 title "Chiral synthons via chloroperoxidase catalysis" @default.
• W2064754955 cites W1507264433 @default.
• W2064754955 cites W1509841066 @default.
• W2064754955 cites W1590377765 @default.
• W2064754955 cites W1633072172 @default.
• W2064754955 cites W1969184136 @default.
• W2064754955 cites W1977160624 @default.
• W2064754955 cites W1982197350 @default.
• W2064754955 cites W1982826653 @default.
• W2064754955 cites W2022478922 @default.
• W2064754955 cites W2026564861 @default.
• W2064754955 cites W2026662914 @default.
• W2064754955 cites W2031593506 @default.
• W2064754955 cites W2034306485 @default.
• W2064754955 cites W2036624293 @default.
• W2064754955 cites W2045531115 @default.
• W2064754955 cites W2047702535 @default.
• W2064754955 cites W2055508803 @default.
• W2064754955 cites W2055552717 @default.
• W2064754955 cites W2058634057 @default.
• W2064754955 cites W2059625827 @default.
• W2064754955 cites W2083887878 @default.
• W2064754955 cites W2093152282 @default.
• W2064754955 cites W2107873308 @default.
• W2064754955 cites W2113119621 @default.
• W2064754955 cites W2124124969 @default.
• W2064754955 cites W2154061135 @default.
• W2064754955 cites W2214742988 @default.
• W2064754955 cites W2949124924 @default.
• W2064754955 cites W2951105362 @default.
• W2064754955 cites W2951164146 @default.
• W2064754955 doi "https://doi.org/10.1016/s1381-1177(98)00013-7" @default.
• W2064754955 hasPublicationYear "1998" @default.
• W2064754955 type Work @default.
• W2064754955 sameAs 2064754955 @default.
• W2064754955 citedByCount "67" @default.
• W2064754955 countsByYear W20647549552012 @default.
• W2064754955 countsByYear W20647549552013 @default.
• W2064754955 countsByYear W20647549552014 @default.
• W2064754955 countsByYear W20647549552015 @default.
• W2064754955 countsByYear W20647549552016 @default.
• W2064754955 countsByYear W20647549552017 @default.
• W2064754955 countsByYear W20647549552019 @default.
• W2064754955 countsByYear W20647549552020 @default.
• W2064754955 countsByYear W20647549552023 @default.
• W2064754955 crossrefType "journal-article" @default.
• W2064754955 hasAuthorship W2064754955A5003813749 @default.
• W2064754955 hasAuthorship W2064754955A5006265865 @default.
• W2064754955 hasAuthorship W2064754955A5062465747 @default.
• W2064754955 hasConcept C109057382 @default.
• W2064754955 hasConcept C111368507 @default.
• W2064754955 hasConcept C127313418 @default.
• W2064754955 hasConcept C134121241 @default.
• W2064754955 hasConcept C161790260 @default.
• W2064754955 hasConcept C178790620 @default.
• W2064754955 hasConcept C181199279 @default.
• W2064754955 hasConcept C181647583 @default.
• W2064754955 hasConcept C185592680 @default.
• W2064754955 hasConcept C191897082 @default.
• W2064754955 hasConcept C192562407 @default.
• W2064754955 hasConcept C2776254738 @default.
• W2064754955 hasConcept C2776920199 @default.
• W2064754955 hasConcept C2777289219 @default.
• W2064754955 hasConcept C2781109383 @default.
• W2064754955 hasConcept C40869318 @default.
• W2064754955 hasConcept C68381374 @default.
• W2064754955 hasConcept C71240020 @default.
• W2064754955 hasConceptScore W2064754955C109057382 @default.
• W2064754955 hasConceptScore W2064754955C111368507 @default.
• W2064754955 hasConceptScore W2064754955C127313418 @default.
• W2064754955 hasConceptScore W2064754955C134121241 @default.
• W2064754955 hasConceptScore W2064754955C161790260 @default.
• W2064754955 hasConceptScore W2064754955C178790620 @default.
• W2064754955 hasConceptScore W2064754955C181199279 @default.
• W2064754955 hasConceptScore W2064754955C181647583 @default.
• W2064754955 hasConceptScore W2064754955C185592680 @default.
• W2064754955 hasConceptScore W2064754955C191897082 @default.
• W2064754955 hasConceptScore W2064754955C192562407 @default.
• W2064754955 hasConceptScore W2064754955C2776254738 @default.
• W2064754955 hasConceptScore W2064754955C2776920199 @default.
• W2064754955 hasConceptScore W2064754955C2777289219 @default.
• W2064754955 hasConceptScore W2064754955C2781109383 @default.
• W2064754955 hasConceptScore W2064754955C40869318 @default.
• W2064754955 hasConceptScore W2064754955C68381374 @default.
• W2064754955 hasConceptScore W2064754955C71240020 @default.
• W2064754955 hasIssue "1-4" @default.
• W2064754955 hasLocation W20647549551 @default.
• W2064754955 hasOpenAccess W2064754955 @default.
• W2064754955 hasPrimaryLocation W20647549551 @default.
• W2064754955 hasRelatedWork W1969929619 @default.
• W2064754955 hasRelatedWork W1971330905 @default.

• next