Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064756065> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2064756065 endingPage "S112" @default.
- W2064756065 startingPage "S112" @default.
- W2064756065 abstract "Hyperbilirubinemia is one of the most common clinical phenomena observed in human newborns. To achieve effective therapeutic treatment, numerous studies have been done to determine the molecular mechanisms of bilirubin-induced neuronal excitotoxicity. However, there is no conclusive evidence for the involvement of glutamatergic synaptic transmission in bilirubin-induced neuronal hyperexcitation and excitotoxicity. In the present study, using gramicidin-perforated patch-clamp techniques, spontaneous excitatory postsynaptic currents (sEPSCs) were recorded from lateral superior olive (LSO) neurons isolated from postnatal 11–14-day-old (P11–14) rats. The application of 3 μM bilirubin increased the frequency, but not the amplitude, of sEPSCs. The action of bilirubin was tetrodotoxin (TTX)-insensitive, as bilirubin also increased the frequency, but not the amplitude, of mEPSCs. The amplitudes of GABA-activated (IGABA) and glutamate-activated (Iglu) currents were not affected by bilirubin. Under current-clamp conditions, no spontaneous action potentials were observed in control solution. However, the application of 3 μM bilirubin for 4–6 min evoked a considerable rate of action-potential firing. The evoked firing was partially occluded by d,l-2-amino-5-phosphonovaleric acid (APV), an NMDA receptor antagonist, but completely inhibited by a combination of APV and 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX), an AMPA receptor antagonist. These results indicate that bilirubin facilitates presynaptic glutamate release, enhances glutamatergic synaptic transmission by activating postsynaptic AMPA and NMDA receptors, and leads to neuronal hyperexcitation. This study provides a better understanding of the mechanism of bilirubin-induced excitotoxicity and determines for the first time that both AMPA and NMDA receptors are likely involved in the excitotoxicity produced by bilirubin." @default.
- W2064756065 created "2016-06-24" @default.
- W2064756065 creator A5015853598 @default.
- W2064756065 creator A5018952575 @default.
- W2064756065 creator A5032497424 @default.
- W2064756065 date "1998-01-01" @default.
- W2064756065 modified "2023-09-25" @default.
- W2064756065 title "Analyses of synaptic plasticity in cultured rat hippocampal slice" @default.
- W2064756065 doi "https://doi.org/10.1016/s0168-0102(98)81967-6" @default.
- W2064756065 hasPublicationYear "1998" @default.
- W2064756065 type Work @default.
- W2064756065 sameAs 2064756065 @default.
- W2064756065 citedByCount "0" @default.
- W2064756065 crossrefType "journal-article" @default.
- W2064756065 hasAuthorship W2064756065A5015853598 @default.
- W2064756065 hasAuthorship W2064756065A5018952575 @default.
- W2064756065 hasAuthorship W2064756065A5032497424 @default.
- W2064756065 hasConcept C112592302 @default.
- W2064756065 hasConcept C12554922 @default.
- W2064756065 hasConcept C160268369 @default.
- W2064756065 hasConcept C169760540 @default.
- W2064756065 hasConcept C170493617 @default.
- W2064756065 hasConcept C17077164 @default.
- W2064756065 hasConcept C185592680 @default.
- W2064756065 hasConcept C189184402 @default.
- W2064756065 hasConcept C197341189 @default.
- W2064756065 hasConcept C200170125 @default.
- W2064756065 hasConcept C2780076171 @default.
- W2064756065 hasConcept C2780648746 @default.
- W2064756065 hasConcept C2781012912 @default.
- W2064756065 hasConcept C2910581834 @default.
- W2064756065 hasConcept C55493867 @default.
- W2064756065 hasConcept C61174792 @default.
- W2064756065 hasConcept C67018056 @default.
- W2064756065 hasConcept C86803240 @default.
- W2064756065 hasConcept C98274493 @default.
- W2064756065 hasConceptScore W2064756065C112592302 @default.
- W2064756065 hasConceptScore W2064756065C12554922 @default.
- W2064756065 hasConceptScore W2064756065C160268369 @default.
- W2064756065 hasConceptScore W2064756065C169760540 @default.
- W2064756065 hasConceptScore W2064756065C170493617 @default.
- W2064756065 hasConceptScore W2064756065C17077164 @default.
- W2064756065 hasConceptScore W2064756065C185592680 @default.
- W2064756065 hasConceptScore W2064756065C189184402 @default.
- W2064756065 hasConceptScore W2064756065C197341189 @default.
- W2064756065 hasConceptScore W2064756065C200170125 @default.
- W2064756065 hasConceptScore W2064756065C2780076171 @default.
- W2064756065 hasConceptScore W2064756065C2780648746 @default.
- W2064756065 hasConceptScore W2064756065C2781012912 @default.
- W2064756065 hasConceptScore W2064756065C2910581834 @default.
- W2064756065 hasConceptScore W2064756065C55493867 @default.
- W2064756065 hasConceptScore W2064756065C61174792 @default.
- W2064756065 hasConceptScore W2064756065C67018056 @default.
- W2064756065 hasConceptScore W2064756065C86803240 @default.
- W2064756065 hasConceptScore W2064756065C98274493 @default.
- W2064756065 hasLocation W20647560651 @default.
- W2064756065 hasOpenAccess W2064756065 @default.
- W2064756065 hasPrimaryLocation W20647560651 @default.
- W2064756065 hasRelatedWork W1978686468 @default.
- W2064756065 hasRelatedWork W1995495469 @default.
- W2064756065 hasRelatedWork W1996815194 @default.
- W2064756065 hasRelatedWork W2004788839 @default.
- W2064756065 hasRelatedWork W2088352169 @default.
- W2064756065 hasRelatedWork W2104417933 @default.
- W2064756065 hasRelatedWork W2122511490 @default.
- W2064756065 hasRelatedWork W2403046355 @default.
- W2064756065 hasRelatedWork W2413886408 @default.
- W2064756065 hasRelatedWork W2897075501 @default.
- W2064756065 hasVolume "31" @default.
- W2064756065 isParatext "false" @default.
- W2064756065 isRetracted "false" @default.
- W2064756065 magId "2064756065" @default.
- W2064756065 workType "article" @default.