FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064757898> ?p ?o ?g. }

• W2064757898 endingPage "649" @default.
• W2064757898 startingPage "645" @default.
• W2064757898 abstract "We investigated the effects of a novel peroxisome proliferator-activated receptor γ (PPARγ) agonist, KR62776, on osteoclast differentiation and function, and on the underlying signaling pathways. KR62776 markedly suppressed differentiation into osteoclasts in various osteoclast model systems, including bone marrow mononuclear (BMM) cells and a co-culture of calvarial osteoblasts and BMM cells. KR62776 suppressed the activation of tartrate-resistant acid phosphatase (TRAP) and the expression of genes associated with osteoclast differentiation, such as TRAP, dendritic cell-specific transmembrane protein (DC-STAMP), and osteoclast-associated receptor (OSCAR). Furthermore, KR62776 reduced resorption pit formation in osteoclasts, and down-regulated genes essential for osteoclast activity, such as Src and αvβ3 integrin. An analysis of a signaling pathway showed that KR62776 inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced activation of p38 mitogen-activated protein kinase (p38MAPK), extracellular regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and nuclear factor-κB (NF-κB). Together, these results demonstrate that KR62776 negatively affects osteoclast differentiation and activity by inhibiting the RANKL-induced activation of MAP kinases and NF-κB." @default.
• W2064757898 created "2016-06-24" @default.
• W2064757898 creator A5005487766 @default.
• W2064757898 creator A5012945820 @default.
• W2064757898 creator A5022063457 @default.
• W2064757898 creator A5030511139 @default.
• W2064757898 creator A5036377621 @default.
• W2064757898 creator A5043503859 @default.
• W2064757898 creator A5045021415 @default.
• W2064757898 creator A5061853198 @default.
• W2064757898 creator A5067863151 @default.
• W2064757898 creator A5068846031 @default.
• W2064757898 creator A5069700719 @default.
• W2064757898 creator A5084473082 @default.
• W2064757898 creator A5089329487 @default.
• W2064757898 date "2009-01-01" @default.
• W2064757898 modified "2023-10-16" @default.
• W2064757898 title "A novel PPARγ agonist, KR62776, suppresses RANKL-induced osteoclast differentiation and activity by inhibiting MAP kinase pathways" @default.
• W2064757898 cites W1484700968 @default.
• W2064757898 cites W1511195742 @default.
• W2064757898 cites W1581720110 @default.
• W2064757898 cites W1633340712 @default.
• W2064757898 cites W1778519373 @default.
• W2064757898 cites W1837114049 @default.
• W2064757898 cites W1965523106 @default.
• W2064757898 cites W1972001482 @default.
• W2064757898 cites W1979029443 @default.
• W2064757898 cites W1987331822 @default.
• W2064757898 cites W2028638661 @default.
• W2064757898 cites W2055224067 @default.
• W2064757898 cites W2065675348 @default.
• W2064757898 cites W2074365374 @default.
• W2064757898 cites W2076963119 @default.
• W2064757898 cites W2093252878 @default.
• W2064757898 cites W2098085126 @default.
• W2064757898 cites W2103185024 @default.
• W2064757898 cites W2104713336 @default.
• W2064757898 cites W2105700895 @default.
• W2064757898 cites W2157476969 @default.
• W2064757898 cites W2163256279 @default.
• W2064757898 cites W4245164999 @default.
• W2064757898 doi "https://doi.org/10.1016/j.bbrc.2008.11.115" @default.
• W2064757898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19059209" @default.
• W2064757898 hasPublicationYear "2009" @default.
• W2064757898 type Work @default.
• W2064757898 sameAs 2064757898 @default.
• W2064757898 citedByCount "23" @default.
• W2064757898 countsByYear W20647578982012 @default.
• W2064757898 countsByYear W20647578982013 @default.
• W2064757898 countsByYear W20647578982014 @default.
• W2064757898 countsByYear W20647578982015 @default.
• W2064757898 countsByYear W20647578982016 @default.
• W2064757898 countsByYear W20647578982021 @default.
• W2064757898 countsByYear W20647578982022 @default.
• W2064757898 crossrefType "journal-article" @default.
• W2064757898 hasAuthorship W2064757898A5005487766 @default.
• W2064757898 hasAuthorship W2064757898A5012945820 @default.
• W2064757898 hasAuthorship W2064757898A5022063457 @default.
• W2064757898 hasAuthorship W2064757898A5030511139 @default.
• W2064757898 hasAuthorship W2064757898A5036377621 @default.
• W2064757898 hasAuthorship W2064757898A5043503859 @default.
• W2064757898 hasAuthorship W2064757898A5045021415 @default.
• W2064757898 hasAuthorship W2064757898A5061853198 @default.
• W2064757898 hasAuthorship W2064757898A5067863151 @default.
• W2064757898 hasAuthorship W2064757898A5068846031 @default.
• W2064757898 hasAuthorship W2064757898A5069700719 @default.
• W2064757898 hasAuthorship W2064757898A5084473082 @default.
• W2064757898 hasAuthorship W2064757898A5089329487 @default.
• W2064757898 hasConcept C104317684 @default.
• W2064757898 hasConcept C134018914 @default.
• W2064757898 hasConcept C148738053 @default.
• W2064757898 hasConcept C153911025 @default.
• W2064757898 hasConcept C170493617 @default.
• W2064757898 hasConcept C184235292 @default.
• W2064757898 hasConcept C185592680 @default.
• W2064757898 hasConcept C2776033226 @default.
• W2064757898 hasConcept C2779428903 @default.
• W2064757898 hasConcept C2909639871 @default.
• W2064757898 hasConcept C55493867 @default.
• W2064757898 hasConcept C57074206 @default.
• W2064757898 hasConcept C62478195 @default.
• W2064757898 hasConcept C673006 @default.
• W2064757898 hasConcept C86803240 @default.
• W2064757898 hasConcept C88045685 @default.
• W2064757898 hasConcept C95444343 @default.
• W2064757898 hasConcept C97029542 @default.
• W2064757898 hasConceptScore W2064757898C104317684 @default.
• W2064757898 hasConceptScore W2064757898C134018914 @default.
• W2064757898 hasConceptScore W2064757898C148738053 @default.
• W2064757898 hasConceptScore W2064757898C153911025 @default.
• W2064757898 hasConceptScore W2064757898C170493617 @default.
• W2064757898 hasConceptScore W2064757898C184235292 @default.
• W2064757898 hasConceptScore W2064757898C185592680 @default.
• W2064757898 hasConceptScore W2064757898C2776033226 @default.
• W2064757898 hasConceptScore W2064757898C2779428903 @default.
• W2064757898 hasConceptScore W2064757898C2909639871 @default.
• W2064757898 hasConceptScore W2064757898C55493867 @default.
• W2064757898 hasConceptScore W2064757898C57074206 @default.

• next