Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064758110> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2064758110 abstract "Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that generally promotes neuronal proliferation, survival and plasticity. These effects occur through cellular secretion and subsequent binding of BDNF to its cognate receptor, TrkB, which promotes paracrine and autocrine signaling cascades. A BDNF/TrkB autocrine loop has been implicated in the survival of cells representing several human cancers and is associated with poor prognosis. The HTLV-1 protein, HBZ, is localized to the nucleus where it is capable of deregulating gene expression. In this study, we found that HBZ increases expression of BDNF. There are a variety of transcriptional variants of BDNF, and HBZ increased expression of several of these. Furthermore, multiple transcriptional variants of BDNF were upregulated in HTLV-1-infected cells compared to normal CD4 cells. Expression of the TrkB receptor was also higher in HTLV-1-infected cells than in normal CD4 cells. This trend similarly occurred when comparing ATL patient and healthy donor specimens, with patient cells exhibiting higher levels of BDNF and TrkB expression. TrkB appeared to localize to the cytoplasmic membrane of HTLV-1-infected cells, suggesting a BDNF/TrkB loop contributes to the survival of these cells. This hypothesis was confirmed by chemically blocking the binding of BDNF to TrkB or by inhibiting TrkB signaling, as both treatments led to a significant increase in apoptosis. Together these results suggest that HBZ activates a BDNF/TrkB autocrine loop that enhances survival of HTLV-1-infected cells. This mechanism may ultimately facilitate the survival of ATL cells." @default.
- W2064758110 created "2016-06-24" @default.
- W2064758110 creator A5008442693 @default.
- W2064758110 creator A5019158258 @default.
- W2064758110 creator A5022174147 @default.
- W2064758110 creator A5035926421 @default.
- W2064758110 creator A5044811584 @default.
- W2064758110 creator A5053575779 @default.
- W2064758110 creator A5062008736 @default.
- W2064758110 creator A5074118856 @default.
- W2064758110 creator A5085124804 @default.
- W2064758110 creator A5089151691 @default.
- W2064758110 date "2014-01-01" @default.
- W2064758110 modified "2023-09-25" @default.
- W2064758110 title "A BDNF/TrKB autocrine loop stimulated by HBZ is involved in HTLV-1-infected cell-survival" @default.
- W2064758110 doi "https://doi.org/10.1186/1742-4690-11-s1-o57" @default.
- W2064758110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4044531" @default.
- W2064758110 hasPublicationYear "2014" @default.
- W2064758110 type Work @default.
- W2064758110 sameAs 2064758110 @default.
- W2064758110 citedByCount "2" @default.
- W2064758110 countsByYear W20647581102014 @default.
- W2064758110 countsByYear W20647581102017 @default.
- W2064758110 crossrefType "journal-article" @default.
- W2064758110 hasAuthorship W2064758110A5008442693 @default.
- W2064758110 hasAuthorship W2064758110A5019158258 @default.
- W2064758110 hasAuthorship W2064758110A5022174147 @default.
- W2064758110 hasAuthorship W2064758110A5035926421 @default.
- W2064758110 hasAuthorship W2064758110A5044811584 @default.
- W2064758110 hasAuthorship W2064758110A5053575779 @default.
- W2064758110 hasAuthorship W2064758110A5062008736 @default.
- W2064758110 hasAuthorship W2064758110A5074118856 @default.
- W2064758110 hasAuthorship W2064758110A5085124804 @default.
- W2064758110 hasAuthorship W2064758110A5089151691 @default.
- W2064758110 hasBestOaLocation W20647581101 @default.
- W2064758110 hasConcept C128240485 @default.
- W2064758110 hasConcept C160539049 @default.
- W2064758110 hasConcept C170493617 @default.
- W2064758110 hasConcept C171034665 @default.
- W2064758110 hasConcept C2778790584 @default.
- W2064758110 hasConcept C502942594 @default.
- W2064758110 hasConcept C54355233 @default.
- W2064758110 hasConcept C7876069 @default.
- W2064758110 hasConcept C86803240 @default.
- W2064758110 hasConcept C92020748 @default.
- W2064758110 hasConcept C95444343 @default.
- W2064758110 hasConcept C97124661 @default.
- W2064758110 hasConceptScore W2064758110C128240485 @default.
- W2064758110 hasConceptScore W2064758110C160539049 @default.
- W2064758110 hasConceptScore W2064758110C170493617 @default.
- W2064758110 hasConceptScore W2064758110C171034665 @default.
- W2064758110 hasConceptScore W2064758110C2778790584 @default.
- W2064758110 hasConceptScore W2064758110C502942594 @default.
- W2064758110 hasConceptScore W2064758110C54355233 @default.
- W2064758110 hasConceptScore W2064758110C7876069 @default.
- W2064758110 hasConceptScore W2064758110C86803240 @default.
- W2064758110 hasConceptScore W2064758110C92020748 @default.
- W2064758110 hasConceptScore W2064758110C95444343 @default.
- W2064758110 hasConceptScore W2064758110C97124661 @default.
- W2064758110 hasIssue "S1" @default.
- W2064758110 hasLocation W20647581101 @default.
- W2064758110 hasLocation W20647581102 @default.
- W2064758110 hasLocation W20647581103 @default.
- W2064758110 hasOpenAccess W2064758110 @default.
- W2064758110 hasPrimaryLocation W20647581101 @default.
- W2064758110 hasRelatedWork W1494002665 @default.
- W2064758110 hasRelatedWork W1509609243 @default.
- W2064758110 hasRelatedWork W1511265793 @default.
- W2064758110 hasRelatedWork W1964028233 @default.
- W2064758110 hasRelatedWork W1966647210 @default.
- W2064758110 hasRelatedWork W1979284753 @default.
- W2064758110 hasRelatedWork W2004670058 @default.
- W2064758110 hasRelatedWork W2022970755 @default.
- W2064758110 hasRelatedWork W2034328033 @default.
- W2064758110 hasRelatedWork W2053546048 @default.
- W2064758110 hasRelatedWork W2063358396 @default.
- W2064758110 hasRelatedWork W2085479798 @default.
- W2064758110 hasRelatedWork W2090245578 @default.
- W2064758110 hasRelatedWork W2121116747 @default.
- W2064758110 hasRelatedWork W2340585084 @default.
- W2064758110 hasRelatedWork W2789344207 @default.
- W2064758110 hasRelatedWork W2900496978 @default.
- W2064758110 hasRelatedWork W2930054187 @default.
- W2064758110 hasRelatedWork W2954056751 @default.
- W2064758110 hasRelatedWork W2999437268 @default.
- W2064758110 hasVolume "11" @default.
- W2064758110 isParatext "false" @default.
- W2064758110 isRetracted "false" @default.
- W2064758110 magId "2064758110" @default.
- W2064758110 workType "article" @default.