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• W2064758814 abstract "<i>Objectives:</i> Multiple sclerosis can be characterized by a strong neuroinflammatory and progressive neurodegenerative component leading to prolonged disability. The synthetic compound R(+)WIN55,212-2 is reported to be neuroprotective at moderate doses and both neuroprotective and immunomodulatory at high doses, most likely due to differences in receptor affinities. In order to investigate the effects of neuroprotection and immunomodulation in an animal model of multiple sclerosis, we examined the impact of increasing concentrations of R(+)WIN55,212-2 on the inflammatory profile in CNS during first relapse and related this to demyelination, axonal degeneration and relapse severity. <i>Methods:</i> Experimental autoimmune encephalomyelitis was induced in Dark Agouti rats and treatment with R(+)WIN55,212-2 was initiated at symptom debut. The animals were scored clinically throughout the experiment, and axonal degeneration, demyelination, T cells, microglia/macrophages, TNF-α, IL-12, IFN-γ, IL-10 and the T_H17 response were estimated at the peak of the first relapse. <i>Results:</i> Treatment with high-dose R(+)WIN55,212-2 (10 and 20 mg/kg) significantly improved the clinical performance of the animals during relapse. Interestingly, treatment at any dosage did not affect the brain levels of TNF-α, IL-12 and IFN-γ (T_H1 response), whereas high-dose cannabinoid treatment reduced the number of T cells and microglia/macrophages in addition to the T_H17 response. At the same time, we observed a significant reduction in axonal degeneration in all treatment groups whereas only high-dose treatment resulted in reduced demyelination. <i>Conclusion:</i> High-dose R(+)WIN55,212-2 treatment reduces demyelination and axonal degeneration and has immunomodulatory effects which significantly improve clinical performance, whereas a reduction in axonal degeneration on its own, induced by 5 mg/kg R(+)WIN55,212-2, has no impact on first relapse severity." @default.
• W2064758814 created "2016-06-24" @default.
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• W2064758814 date "2010-01-01" @default.
• W2064758814 modified "2023-09-23" @default.
• W2064758814 title "Neuroprotection without Immunomodulation Is Not Sufficient to Reduce First Relapse Severity in Experimental Autoimmune Encephalomyelitis" @default.
• W2064758814 cites W14049348 @default.
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• W2064758814 cites W1537351363 @default.
• W2064758814 cites W1556923935 @default.
• W2064758814 cites W1785819613 @default.
• W2064758814 cites W1790460690 @default.
• W2064758814 cites W1956139961 @default.
• W2064758814 cites W1959664751 @default.
• W2064758814 cites W1964111698 @default.
• W2064758814 cites W1965575030 @default.
• W2064758814 cites W197245174 @default.
• W2064758814 cites W1974430505 @default.
• W2064758814 cites W1975179491 @default.
• W2064758814 cites W1977715122 @default.
• W2064758814 cites W1979993194 @default.
• W2064758814 cites W1989090634 @default.
• W2064758814 cites W1989737013 @default.
• W2064758814 cites W1989805761 @default.
• W2064758814 cites W1993688922 @default.
• W2064758814 cites W1996244205 @default.
• W2064758814 cites W1996712837 @default.
• W2064758814 cites W1999711723 @default.
• W2064758814 cites W2000872418 @default.
• W2064758814 cites W2006249161 @default.
• W2064758814 cites W2009514426 @default.
• W2064758814 cites W2017517720 @default.
• W2064758814 cites W2017863141 @default.
• W2064758814 cites W2018673898 @default.
• W2064758814 cites W2023188936 @default.
• W2064758814 cites W2031114852 @default.
• W2064758814 cites W2031231765 @default.
• W2064758814 cites W2032715817 @default.
• W2064758814 cites W2034049482 @default.
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• W2064758814 cites W2046748764 @default.
• W2064758814 cites W2047214716 @default.
• W2064758814 cites W2050143416 @default.
• W2064758814 cites W2051086257 @default.
• W2064758814 cites W2052598278 @default.
• W2064758814 cites W2053195789 @default.
• W2064758814 cites W2060589571 @default.
• W2064758814 cites W2066955303 @default.
• W2064758814 cites W2074247105 @default.
• W2064758814 cites W2081354276 @default.
• W2064758814 cites W2081810711 @default.
• W2064758814 cites W2090028614 @default.
• W2064758814 cites W2091408180 @default.
• W2064758814 cites W2095085207 @default.
• W2064758814 cites W2097503043 @default.
• W2064758814 cites W2103904373 @default.
• W2064758814 cites W2106741667 @default.
• W2064758814 cites W2108617074 @default.
• W2064758814 cites W2112832626 @default.
• W2064758814 cites W2113319670 @default.
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• W2064758814 cites W2267888430 @default.
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• W2064758814 doi "https://doi.org/10.1159/000290041" @default.
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