FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064759711> ?p ?o ?g. }

• W2064759711 endingPage "6314" @default.
• W2064759711 startingPage "6309" @default.
• W2064759711 abstract "Many bioactive peptides, presenting an unstructured conformation in aqueous solution, are made resistant to degradation by posttranslational modifications. Here, we describe how molecular oligomerization in aqueous solution can generate a still unknown transport form for amphipathic peptides, which is more compact and resistant to proteases than forms related to any possible monomer. This phenomenon emerged from 3D structure, function, and degradation properties of distinctin, a heterodimeric antimicrobial compound consisting of two peptide chains linked by a disulfide bond. After homodimerization in water, this peptide exhibited a fold consisting of a symmetrical full-parallel four-helix bundle, with a well secluded hydrophobic core and exposed basic residues. This fold significantly stabilizes distinctin against proteases compared with other linear amphipathic peptides, without affecting its antimicrobial, hemolytic, and ion-channel formation properties after membrane interaction. This full-parallel helical orientation represents a perfect compromise between formation of a stable structure in water and requirement of a drastic structural rearrangement in membranes to elicit antimicrobial potential. Thus, distinctin can be claimed as a prototype of a previously unrecognized class of antimicrobial derivatives. These results suggest a critical revision of the role of peptide oligomerization whenever solubility or resistance to proteases is known to affect biological properties." @default.
• W2064759711 created "2016-06-24" @default.
• W2064759711 creator A5021132791 @default.
• W2064759711 creator A5026703830 @default.
• W2064759711 creator A5051179514 @default.
• W2064759711 creator A5053875999 @default.
• W2064759711 creator A5061315099 @default.
• W2064759711 creator A5062545741 @default.
• W2064759711 creator A5063232427 @default.
• W2064759711 creator A5066685728 @default.
• W2064759711 creator A5070623531 @default.
• W2064759711 creator A5078680549 @default.
• W2064759711 date "2005-04-19" @default.
• W2064759711 modified "2023-10-02" @default.
• W2064759711 title "A folding-dependent mechanism of antimicrobial peptide resistance to degradation unveiled by solution structure of distinctin" @default.
• W2064759711 cites W1522259447 @default.
• W2064759711 cites W1964366280 @default.
• W2064759711 cites W1968732465 @default.
• W2064759711 cites W1973173834 @default.
• W2064759711 cites W1976301815 @default.
• W2064759711 cites W1981935195 @default.
• W2064759711 cites W1988901585 @default.
• W2064759711 cites W1990519548 @default.
• W2064759711 cites W1992718795 @default.
• W2064759711 cites W1997868832 @default.
• W2064759711 cites W2002066211 @default.
• W2064759711 cites W2006567425 @default.
• W2064759711 cites W2007446604 @default.
• W2064759711 cites W2013896356 @default.
• W2064759711 cites W2021284027 @default.
• W2064759711 cites W2022058405 @default.
• W2064759711 cites W2024313783 @default.
• W2064759711 cites W2025230440 @default.
• W2064759711 cites W2026992955 @default.
• W2064759711 cites W2041654237 @default.
• W2064759711 cites W2047980114 @default.
• W2064759711 cites W2054602599 @default.
• W2064759711 cites W2055805017 @default.
• W2064759711 cites W2068434462 @default.
• W2064759711 cites W2076755375 @default.
• W2064759711 cites W2085277871 @default.
• W2064759711 cites W2085507541 @default.
• W2064759711 cites W2098164044 @default.
• W2064759711 cites W2108067237 @default.
• W2064759711 cites W2121697748 @default.
• W2064759711 cites W2146427607 @default.
• W2064759711 cites W2158482458 @default.
• W2064759711 cites W2160780417 @default.
• W2064759711 cites W2168055563 @default.
• W2064759711 doi "https://doi.org/10.1073/pnas.0409004102" @default.
• W2064759711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1088359" @default.
• W2064759711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15840728" @default.
• W2064759711 hasPublicationYear "2005" @default.
• W2064759711 type Work @default.
• W2064759711 sameAs 2064759711 @default.
• W2064759711 citedByCount "64" @default.
• W2064759711 countsByYear W20647597112012 @default.
• W2064759711 countsByYear W20647597112013 @default.
• W2064759711 countsByYear W20647597112014 @default.
• W2064759711 countsByYear W20647597112015 @default.
• W2064759711 countsByYear W20647597112016 @default.
• W2064759711 countsByYear W20647597112017 @default.
• W2064759711 countsByYear W20647597112018 @default.
• W2064759711 countsByYear W20647597112019 @default.
• W2064759711 countsByYear W20647597112020 @default.
• W2064759711 countsByYear W20647597112022 @default.
• W2064759711 countsByYear W20647597112023 @default.
• W2064759711 crossrefType "journal-article" @default.
• W2064759711 hasAuthorship W2064759711A5021132791 @default.
• W2064759711 hasAuthorship W2064759711A5026703830 @default.
• W2064759711 hasAuthorship W2064759711A5051179514 @default.
• W2064759711 hasAuthorship W2064759711A5053875999 @default.
• W2064759711 hasAuthorship W2064759711A5061315099 @default.
• W2064759711 hasAuthorship W2064759711A5062545741 @default.
• W2064759711 hasAuthorship W2064759711A5063232427 @default.
• W2064759711 hasAuthorship W2064759711A5066685728 @default.
• W2064759711 hasAuthorship W2064759711A5070623531 @default.
• W2064759711 hasAuthorship W2064759711A5078680549 @default.
• W2064759711 hasBestOaLocation W20647597111 @default.
• W2064759711 hasConcept C119599485 @default.
• W2064759711 hasConcept C12554922 @default.
• W2064759711 hasConcept C127413603 @default.
• W2064759711 hasConcept C15920480 @default.
• W2064759711 hasConcept C178790620 @default.
• W2064759711 hasConcept C181199279 @default.
• W2064759711 hasConcept C182220744 @default.
• W2064759711 hasConcept C184651966 @default.
• W2064759711 hasConcept C185592680 @default.
• W2064759711 hasConcept C21951064 @default.
• W2064759711 hasConcept C2776545253 @default.
• W2064759711 hasConcept C2779281246 @default.
• W2064759711 hasConcept C47701112 @default.
• W2064759711 hasConcept C4937899 @default.
• W2064759711 hasConcept C521977710 @default.
• W2064759711 hasConcept C540938839 @default.
• W2064759711 hasConcept C55493867 @default.
• W2064759711 hasConcept C67407626 @default.
• W2064759711 hasConcept C71240020 @default.

• next