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• W2064759860 abstract "Objective. This study was designed to document the frequency and define the clinical, epidemiologic, and microbiologic characteristics of perineal disease caused by group A β-hemolytic streptococci (GAS) in a pediatric practice in which increased numbers of cases had been observed. Methods. Clinical, epidemiologic, and microbiologic data were collected on all culture-confirmed cases of perineal GAS disease during the calendar year 1997. GAS isolates from clinical cases and a comparison group of children with GAS pharyngitis were analyzed by T typing, emm gene analysis, and pulsed-field gel electrophoresis (PFGE). Results. Twenty-three cases of GAS perineal disease were diagnosed during 4530 office visits in 1997. Thirteen cases had perianal disease, 8 had vulvovaginal infection, and 2 were infected at both sites. No cases of penile disease were identified. Infections peaked in late winter and early spring and affected children with an average age of 5 years with a range of perineal, gastrointestinal, and genitourinary symptoms. Analysis of T and emm types showed the majority (82%) of perineal isolates to be T 28emm 28, showing 2 closely related PFGE patterns. In contrast, the pharyngeal isolates were distributed among 6 different T and emm types. Conclusion. Perineal infection caused by GAS may be a relatively common diagnosis in a pediatric or family practice setting. There may be specific GAS types that have a tropism for perineal tissues but the mechanism of infection is yet to be established." @default.
• W2064759860 created "2016-06-24" @default.
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• W2064759860 date "2000-08-01" @default.
• W2064759860 modified "2023-10-14" @default.
• W2064759860 title "Perineal Group A Streptococcal Disease in a Pediatric Practice" @default.
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• W2064759860 doi "https://doi.org/10.1542/peds.106.2.276" @default.
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