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- W2064760034 abstract "IT IS NOW well established that anti−thyroid drugs such as thioura−cil prevent the formation of thyroid hormone. As the mechanism of this action is still obscure it seemed likely that studies on the iodine metabolism of the thyroid gland would provide useful information. In view of the fact that the iodine content of the thyroid gland re−flects the quantity of active principle contained therein, measure−ments of the iodine concentration under various experimental condi−tions might be expected to define more exactly the changes brought about by anti−thyroid drugs in the synthesis of thyroid hormone. Abnormally low concentrations of iodine in the thyroid have been noted in the simple colloid goiters which occur in regions of iodine deficiency, in the hyperplastic glands of hyperthyroid patients, in the goiters experimentally produced by iodine deficient and goitrigenic diets, and in the hyperplastic thyroids resulting from the injection of pituitary extracts." @default.
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- W2064760034 date "1944-04-01" @default.
- W2064760034 modified "2023-09-27" @default.
- W2064760034 title "EFFECT OF THIOURACIL ON THE IODINE CONTENT OF THE THYROID GLAND<sup>1</sup>" @default.
- W2064760034 doi "https://doi.org/10.1210/endo-34-4-282" @default.
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