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- W2064763922 abstract "Abstract The desensitization of the muscarinic receptor, of which activation is known to depress the ionic K + and Ca 2+ currents generated during action potentials of bullfrog sympathetic ganglion cells, was studied. The depression of these voltage-dependent K + and Ca 2+ currents by muscarinic action of acetylcholine (ACh) was gradually restored to a certain extent when an application of ACh was sustained. After removal of ACh, the sensitivity of the muscarinic receptor was still depressed for an extended period, while resting and action potentials were apparently observed to be of normal level and size, respectively. These results indicate that desensitization of muscarinic receptors developed during a sustained application of ACh. It was suggested that the muscarinic receptor controlling these voltage-dependent currents of ganglion cells may be part of receptor-ionic channel complex (RICC) the nature of which was comparable to that of the RICC of the nicotinic receptor of the end-plate." @default.
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- W2064763922 date "1980-12-01" @default.
- W2064763922 modified "2023-09-26" @default.
- W2064763922 title "Desensitization of the muscarinic receptor controlling action potentials of sympathetic ganglion cells in bullfrogs" @default.
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- W2064763922 doi "https://doi.org/10.1016/0024-3205(80)90393-8" @default.
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