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- W2064792484 abstract "We would like to thank all the commentators for their thoughtful and constructive criticisms which will undoubtedly advance debate on this topic. We share the skepticism of some of the commentators about establishing a global hESC bank now or in the near future. We agree that there are remaining uncertainties about the immunological status of such cells as well as substantial, ongoing limitations in developing solid organs for transplantation (Ecker and O’Rourke 2007; Master and Williams-Jones 2007). Whether human leukocyte antigen (HLA)-matching, cross-reactive epitope group (CREG)matching, or another immunocompatibility standard is ultimately adopted, we nevertheless think it is important to embed this empirical reality of hESC science into ethical reasoning regarding the concept of a global hESC bank. We have attempted, in part, to provide an immunologicallydriven blueprint for the creation of such a bank. As with all plans, however, the particulars may change, but we hope the architectural principles will endure. We also recognize that there are no clinically relevant stem cell-based therapies available now (Ecker and O’Rourke 2007). We entirely agree with Master and Williams-Jones (2007) that before a global hESC bank is established, “there must first be clear scientific evidence demonstrating the feasibility of and likelihood that the proposed benefits (i.e., immune tailored transplantable tissues and organs) will ensue” (45). We are not suggesting that a global hESC bank should be established immediately but rather when therapies become reality. That Master and Williams-Jones contend that “altering research ethics norms based on unsubstantiated or unjustified scientific evidence is simply morally irresponsible” (45) suggests a myopic view of the bioethical enterprise, which is charged as much with anticipating and understanding future scientific and clinical developments as it is dealing with current controversies (Lott 2005)." @default.
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- W2064792484 date "2007-08-07" @default.
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- W2064792484 title "A Response to Commentators on “Towards a Global Human Embryonic Stem Cell Bank”" @default.
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- W2064792484 doi "https://doi.org/10.1080/15265160701577686" @default.
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