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- W2064803105 abstract "Isoguanosine has been incorporated into a 34-mer hammerhead ribozyme by the solid-phase phosphoramidite method, using an acetamidine base protecting group. The activity of the hammerhead ribozyme when singly mutated to isoguanosine at the adenosine positions 6, 9, and 13 was 1-2-fold less than the wild-type activity. Mutations to 2-aminopurine ribonucleoside at positions 9 and 13 were 5-fold reduced in activity, but that at position 6 was approximately 30-fold reduced. These results support the view that the 6-amino functions of A6, A9, and A13 are not very important for catalysis. The 2-position of A6 tolerates a carbonyl function but not an amino group, whereas A9 and A13 tolerate both functional groups. The tolerance of a 2-amino group at A9 and A13 makes G(anti)/A(anti) Watson-Crick type base mispairing for G12/A9 and A13/G8 unlikely." @default.
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- W2064803105 date "1994-10-11" @default.
- W2064803105 modified "2023-09-23" @default.
- W2064803105 title "Isoguanosine Substitution of Conserved Adenosines in the Hammerhead Ribozyme" @default.
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- W2064803105 doi "https://doi.org/10.1021/bi00206a015" @default.
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