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• W2064803521 abstract "Summary. Background: The endocannabinoid 2-arachidonoylglycerol (2-AG) is an endogenous lipid that acts through the activation of G-protein-coupled cannabinoid receptors and plays essential roles in many physiological contexts. In the cardiovascular system 2-AG is generated by both activated endothelial cells and platelets, and participates in the regulation of inflammation and thrombosis. Although human platelets actively metabolize endocannabinoids, 2-AG also binds to platelet surface and leads to cell activation. Objective: To investigate the biological consequence of 2-AG interactions with human platelets and to clarify the role of cannabinoid receptors. Methods: Gel-filtered platelets were stimulated with 2-AG in the presence or absence of various inhibitors. Platelet aggregation and secretion were measured in a lumiaggregometer. Calcium ion movements were measured in FURA-2 loaded platelets. Thromboxane A2 (TxA2) generation was evaluated as Thromboxane B2 accumulation with a commercial EIA assay. Results: 2-AG induced platelet shape change, aggregation and secretion with a dose-dependent mechanism that required engagement of platelet TxA2 receptors. 2-AG caused also cytosolic calcium increase; however, it was totally dependent on availability of TxA2. Indeed 2-AG was able to induce a robust generation of TxA2 through the cyclooxygenase pathway. Treatment of platelets with inhibitors of monoacylglycerol lipase and fatty acid amide hydrolase did not affect the activation induced by 2-AG. Moreover, neither CB1 and CB2 proteins nor CB1/CB2 mRNAs were detected in platelets. Conclusions: 2-AG can be considered a new physiologic platelet agonist able to induce full platelet activation and aggregation with a non-CB1/CB2 receptor-mediated mechanism." @default.
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• W2064803521 date "2008-10-01" @default.
• W2064803521 modified "2023-10-16" @default.
• W2064803521 title "The endocannabinoid 2‐arachidonoylglycerol activates human platelets through non‐CB1/CB2 receptors" @default.
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• W2064803521 doi "https://doi.org/10.1111/j.1538-7836.2008.03093.x" @default.
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